ArticleNature communications2023
Strong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Sea Cucumber-Inspired Double-Network Biopolymer Hydrogels for Programmable Soft Machines.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Asymmetric Doping of a Polyelectrolyte Network Into a Tough Slide-Ring Hydrogel Membrane to Enhance Sustainable Osmotic Energy Harvesting.Small science · 2026Article
- Bioinspired Sarcomeric Double-Network Hydrogels for Programmable Mechanics with Ultralow Hysteresis.Gels (Basel, Switzerland) · 2026Article
- Musculoskeletal Ultrasound and Protein-Based Hydrogels: Novel Approaches for the Diagnosis and Treatment of Sports Injuries.Polymers · 2026Review
- Thermal-driven H-bond reconfiguration for bioinspired high-strength anisotropic supramolecular hydrogels.Materials horizons · 2026Article
- Nanoscale Covalent Organic Framework Confinement Enables Ultratough and Hyperelastic Hydrogels Applied as High-Performance Electrolytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hierarchical picot-fiber hydrogel coating with ultralow friction and high wear resistance.Nature communications · 2026Article
- Bionic Janus hydrogel drives infected Achilles tendon regeneration via mechano-immune spatiotemporal steering.Nature communications · 2026Article
- Application of Colloid Material in Prevention and Control of Coal Spontaneous Combustion in Coal Mine.ACS omega · 2026Review
- Microscale Architectures for Intelligent Soft Robotics: From Functional Microneedles to Biointegrated Wearable Systems.Nano-micro letters · 2026Review
- Hydrogels in Neurological Disorders: Emerging Diagnostic and Therapeutic Applications.International journal of nanomedicine · 2026Review
- Tough and tear resistant hydrogel with a sandwich mineralized structure induced by bidirectional ion migration.Nature communications · 2025Article
- Engineered self-assembling hydrogel systems for advanced guided bone regeneration: structural optimization and biofunctional modulation.Journal of nanobiotechnology · 2025Review
- Shape Memory Collagen Scaffolds Sustain Large-Scale Cyclic Loading.ACS materials letters · 2025Article
- Enzyme-Triggered Formation of Tensegrity Structures for Mechanospatial Manipulation of Hydrogels.Gels (Basel, Switzerland) · 2025Article
- Mechanically robust eutectogels enabled by precisely engineered crystalline domains.Nature communications · 2025Article
- Peptide-based rigid nanorod-reinforced gelatin methacryloyl hydrogels for osteochondral regeneration and additive manufacturing.Nature communications · 2025Article
- Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Biodegradable photosensitive antimicrobial hydrogel film based on curcumin-carbon dots for raw meat preservation.Food chemistry: X · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogels are promising soft materials as tissue engineering scaffolds, stretchable sensors, and soft robotics. Yet, it remains challenging to develop synthetic hydrogels with mechanical stability and durability similar to those of the connective tissues. Many of the necessary mechanical properties, such as high strength, high toughness, rapid recovery, and high fatigue resistance, generally cannot be established together using conventional polymer networks. Here we present a type of hydrogels comprising hierarchical structures of picot fibres made of copper-bound self-assembling peptide strands with zipped flexible hidden length. The redundant hidden lengths allow the fibres to be extended to dissipate mechanical load without reducing network connectivity, making the hydrogels robust against damage. The hydrogels possess high strength, good toughness, high fatigue threshold, and rapid recovery, comparable to or even outperforming those of articular cartilage. Our study highlights the unique possibility of tailoring hydrogel network structures at the molecular level to improve their mechanical performance.
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