ArticleNature communications2023
Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- 14-3-3 proteins: Central hubs in plant development and stress adaptation.Journal of integrative plant biology · 2026Review
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- Genome-wide transcriptional analysis of 14-3-3 genes in Paulownia fortunei under abiotic and biotic stresses.BMC plant biology · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- Insights and applications for understanding the allergology, immunology and biotechnology of plant systems.Molecular biology reports · 2026Review
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The CBP60b-14-3-3 functional module regulates immunity in arabidopsis.Frontiers in plant science · 2026Article
- Function and defense mechanisms of wheat 14-3-3 protein TaGF14a in stripe rust resistance.BMC biology · 2025Article
- A Secretory Protein Laccase lac8 From Pathogenic Fungi Activates Plant Protein 14-3-3 and Leucine-Rich Repeat Receptor-Like Protein LRR-RLP1 to Trigger Mango Immunity.Molecular plant pathology · 2025Article
- Silenced cutters: mechanisms and effects of protease inhibition in plant-pathogen interactions.Journal of experimental botany · 2025Review
- The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in Nicotiana benthamiana prf mutants.Plant physiology · 2025Article
- Article
- Receptor-like cytoplasmic kinases mediated signaling in plant immunity: convergence and divergence.Stress biology · 2025Review
- Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector.PLoS genetics · 2025Article
- Proteomic Analysis of Plants with Binding Immunoglobulin Protein Overexpression Reveals Mechanisms Related to Defense AgainstPlants (Basel, Switzerland) · 2025Article
- The effector-triggered immunity landscape of tomato against Pseudomonas syringae.Nature communications · 2024Article
- A 14-3-3 Protein Ca16R Acts Positively in Pepper Immunity againstPlants (Basel, Switzerland) · 2024Article
- Paired plant immune CHS3-CSA1 receptor alleles form distinct hetero-oligomeric complexes.Science (New York, N.Y.) · 2024Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 6 countries.
Funding
Abstract
In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity. In plants, NLRs recognise pathogen-derived effector proteins and initiate effector-triggered immunity (ETI). However, the molecular mechanisms that link NLR-mediated effector recognition and downstream signalling are not fully understood. By exploiting the well-characterised tomato Prf/Pto NLR resistance complex, we identified the 14-3-3 proteins TFT1 and TFT3 as interacting partners of both the NLR complex and the protein kinase MAPKKKα. Moreover, we identified the helper NRC proteins (NLR-required for cell death) as integral components of the Prf /Pto NLR recognition complex. Notably our studies revealed that TFTs and NRCs interact with distinct modules of the NLR complex and, following effector recognition, dissociate facilitating downstream signalling. Thus, our data provide a mechanistic link between activation of immune receptors and initiation of downstream signalling cascades.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.