ArticleNature communications2023
Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Advances in Research on Models of Oligoasthenozoospermia.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Integrated Analysis of Testicular Histology, Sperm Quality, and Gene Expression (Animals : an open access journal from MDPI · 2026Article
- Distinct macronutrient ratios optimize offspring survival, growth, and maternal glucose tolerance across mouse reproduction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Environmental influences on seminal plasma: Molecular and functional insights.The Journal of reproduction and development · 2026Review
- Joint and individual associations between multiple vitamins and sperm quality in adult men.Frontiers in nutrition · 2025Article
- Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring.Nature communications · 2024Article
- Dietary macronutrient composition impacts gene regulation in adipose tissue.Communications biology · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework to examine the effects of dietary macronutrient balance on reproductive traits in C57BL/6 J male mice. Dietary effects are observed in a range of morphological, testicular and spermatozoa traits, although the relative influence of protein, fat, carbohydrate, and their interactions differ depending on the trait being examined. Interestingly, dietary fat has a positive influence on sperm motility and antioxidant capacity, differing to typical high fat diet studies where calorie content is not controlled for. Moreover, body adiposity is not significantly correlated with any of the reproductive traits measured in this study. These results demonstrate the importance of macronutrient balance and calorie intake on reproductive function and support the need to develop specific, targeted, preconception dietary guidelines for males.
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Registered trials
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