Evidence map›Paper›PMID 37142497›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023

Physiological and introspective antecedents of tics and movements in adults with tic disorders.

Antonio I Triggiani, Kaya Scheman, Sarah Pirio Richardson, Masao Matsuhashi, Elizabeth Peckham, Fatta Nahab, Zoltan Mari, Shashi Ravindran, Mark Hallett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Factors that influence the amplitude of the bereitschaftspotential.Neuroscience and biobehavioral reviews · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Antonio I TriggianiHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address: antonio.triggiani@nih.gov.
Kaya SchemanHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address: kaya.scheman@nih.gov.
Sarah Pirio RichardsonHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States. Electronic address: spiriorichardson@salud.unm.edu.
Masao MatsuhashiHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: matsuhashi@kuhp.kyoto-u-ac.jp.
Elizabeth PeckhamHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; Central Texas Neurology Consultants, Round Rock, TX, United States. Electronic address: e.peckham@ctncpa.org.
Fatta NahabHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; Department of Neurosciences, Movement Disorder Center, University of California, San Diego, San Diego, CA, United States. Electronic address: fnahab@ucsd.edu.
Zoltan MariHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States. Electronic address: mariz@ccf.org.
Shashi RavindranHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address: shashi.ravindran@nih.gov.
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address: hallettm@ninds.nih.gov.
National Institutes of Health · US

Funding

PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTSZ01NS002667 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK A · 1985 to 2008
$2.2M
Intramural NIH HHS Z01 NS002667
6 · The paper itself

Abstract

objectiveTo investigate the subjective phenomenon and the neural underpinnings of tics compared with voluntary movements in patients with tic disorders.

methodsWe recorded electroencephalographic and electromyographic data while subjects completed a Libet clock paradigm. Patients and healthy volunteers reported the times of W (willing to move) and M (movement occurrence) while performing voluntary movements. This was repeated only for the patients for the tics.

resultsIn the patients, W and M times preceding voluntary movements and tics did not significantly differ from voluntary movements of healthy volunteers. The Bereitschaftspotentials in the patients were similar to healthy volunteers. Tics were only assessable for 7 patients due to artifacts. Two subjects did not show Bereitschaftspotentials, and they reported the lowest levels of tic voluntariness. 5 subjects did not show beta band event-related desynchronization before tics.

conclusionsFor patients, the sense of volition for tics is similar to that of their voluntary movements which is similar to normal. Patients showed dissociations between the Bereitschaftspotential and beta desynchronization for tics, with 5/7 showing normal Bereitschaftspotentials and 2/7 showing desynchronization. The absence of desynchronization may suggest attempts to suppress tics. SIGNIFICANCE: This physiology shows a difference for most tics compared with normal movements.

Indexed as

Tic DisordersTicsTourette SyndromeAdultContingent Negative VariationElectroencephalographyHumansMovementBereitschaftspotentialElectroencephalographyEvent-related desynchronizationLibet’s clockTic

Identifiers

PMID37142497
PMCPMC10330543
OpenAlexW4366245958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.