ArticleBritish journal of anaesthesia2023
Oestrous cycle affects emergence from anaesthesia with dexmedetomidine, but not propofol, isoflurane, or sevoflurane, in female rats.
Article in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06003127 (REcovery From DEXmedetomidine-induced Unconsciousness), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REcovery From DEXmedetomidine-induced Unconsciousness
Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- The effects of desflurane on male rat reproductive hormones, testicular tissue, and sperm morphology: an experimental study.BMC anesthesiology · 2026Article
- Inflammatory and Redox Mediators in Rat and Human Ovulation.International journal of molecular sciences · 2025Review
- Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice.Scientific reports · 2025Article
- Drug-specific recovery of long-term memory and visual discrimination after anaesthetic-induced unconsciousness in rats.British journal of anaesthesia · 2025Article
- Copper Ion and Tannic Acid Polyphenol-Metal Scaffold Loaded with Curcumin Promote Skin Wound Healing.ACS omega · 2025Article
- Analysis of conditioning with dexmedetomidine under endothelial dysfunction in isolated perfused hearts.Biomedical reports · 2025Article
- Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management.Current issues in molecular biology · 2025Review
- Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial.BJA open · 2025Article
- Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic-ischemic encephalopathy rats.Cell death & disease · 2025Article
- REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy Volunteers.Nature and science of sleep · 2025Article
- Role of dorsal striatum circuits in relapse to opioid seeking after voluntary abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Exogenous Ketone Supplement Administration Abrogated Isoflurane-Anesthesia-Induced Increase in Blood Glucose Level in Female WAG/Rij Rats.Nutrients · 2024Article
- Hormonal basis of sex differences in anesthetic sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Clinical adverse events to dexmedetomidine: a real-world drug safety study based on the FAERS database.Frontiers in pharmacology · 2024Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlthough sex differences in anaesthetic sensitivity have been reported, what underlies these differences is unknown. In rodents, one source of variability in females is the oestrous cycle. Here we test the hypothesis that the oestrous cycle impacts emergence from general anaesthesia.
methodsTime to emergence was measured after isoflurane (2 vol% for 1 h), sevoflurane (3 vol% for 20 min), dexmedetomidine (50 μg kg
resultsOestrous cycle did not affect righting latency after isoflurane, sevoflurane, or propofol. When in the early dioestrus stage, rats emerged more rapidly from dexmedetomidine than in the proestrus (P=0.0042) or late dioestrus (P=0.0230) stage and showed reduced overall power in frontal EEG spectra 30 min after dexmedetomidine (P=0.0049). 17β-Oestradiol and progesterone serum concentrations did not correlate with righting latency. Oestrous cycle did not affect mean arterial blood pressure or blood gases during dexmedetomidine.
conclusionsIn female rats, the oestrous cycle significantly impacts emergence from dexmedetomidine-induced unconsciousness. However, 17β-oestradiol and progesterone serum concentrations do not correlate with the observed changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.