Evidence map›Paper›PMID 37142433›Full record

ArticleAJNR. American journal of neuroradiology2023

Improved Myelination following Camp Leg Power, a Selective Motor Control Intervention for Children with Spastic Bilateral Cerebral Palsy: A Diffusion Tensor MRI Study.

A Vuong, S H Joshi, L A Staudt, J H Matsumoto, E G Fowler

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07310550 (Physical Therapy Program for Selective Motor Control), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07310550 nacompletednot on this map

Physical Therapy Program for Selective Motor Control

TypeinterventionalSponsorUniversity of California, Los AngelesRan2014 to 2019Enrolled23ConditionsSpastic Cerebral PalsyArmsSelective movement of individual lower limb joints, Knee joint strengthening at high velocities, Ankle controlled gaming, Functional activities based on child and parental goals, Sensori-motor exercises
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Functional and Structural Neural Plasticity Following sEMG Control of a Virtual Prosthetic Hand in an Individual with Bilateral Upper-Limb Congenital Amputation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

A VuongFrom the Departments of Bioengineering (A.V., S.H.J.) andyvuong@ucla.edu.ORCID 0000-0002-7065-8436
S H JoshiFrom the Departments of Bioengineering (A.V., S.H.J.).ORCID 0000-0003-1287-7005
L A StaudtOrthopaedic Surgery (A.V., L.A.S., E.G.F.).ORCID 0000-0002-8089-9911
J H MatsumotoPediatrics (J.H.M.), University of California Los Angeles, Los Angeles, California.ORCID 0000-0002-4861-5237
E G FowlerOrthopaedic Surgery (A.V., L.A.S., E.G.F.).ORCID 0000-0002-3806-4064
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
NCATS NIH HHS UL1 TR001881
6 · The paper itself

Abstract

background and purposeChildren with spastic cerebral palsy have motor deficits associated with periventricular leukomalacia indicating WM damage to the corticospinal tracts. We investigated whether practice of skilled lower extremity selective motor control movements would elicit neuroplasticity. MATERIALS AND

methodsTwelve children with spastic bilateral cerebral palsy and periventricular leukomalacia born preterm (mean age, 11.5 years; age range, 7.3-16.6 years) participated in a lower extremity selective motor control intervention, Camp Leg Power. Activities promoted isolated joint movement including isokinetic knee exercises, ankle-controlled gaming, gait training, and sensorimotor activities (3 hours/day, 15 sessions, 1 month). DWI scans were collected pre- and postintervention. Tract-Based Spatial Statistics was used to analyze changes in fractional anisotropy, radial diffusivity, axial diffusivity, and mean diffusivity.

resultsSignificantly reduced radial diffusivity (

conclusionsMyelination of the corticospinal tracts improved following Camp Leg Power. Neighboring WM changes suggest recruitment of additional tracts involved in regulating neuroplasticity of the motor regions. Intensive practice of skilled lower extremity selective motor control movements promotes neuroplasticity in children with spastic bilateral cerebral palsy.

Indexed as

Cerebral PalsyLeukomalacia, PeriventricularWhite MatterAdolescentAnisotropyChildDiffusion Tensor ImagingHumansInfant, NewbornLegLower ExtremityMuscle Spasticity

Identifiers

PMID37142433
PMCPMC10249693
OpenAlexW4368355032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.