ArticleCell metabolism2023
Organism-wide, cell-type-specific secretome mapping of exercise training in mice.
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Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57citing papers in PubMed, 1 pooled it
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57 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Exercise modalities and dosages on glycated haemoglobin and exerkines in type 2 diabetes: a systematic review with pairwise, network, and dose-response meta-analyses.Cardiovascular diabetology · 2026Pooled it
- Adipose tissue as a humoral-neuronal hub in metabolic regulation.Nature reviews. Endocrinology · 2026Review
- Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans.Cell reports. Medicine · 2026Article
- Endurance exercise elicits a hepatic memory associated with improved metabolic function and protein secretion.Molecular metabolism · 2026Article
- Systematic Targeting of Protein Complexes with Molecular COUPLrs.Cancer discovery · 2026Article
- Spatiotemporally Resolved Protein Tagging for Dynamic and Tissue-Specific Secretome Profiling In Vivo.Angewandte Chemie (International ed. in English) · 2026Article
- Proximal labeling of the Golgi secretome reveals fat body-derived humoral factors in Drosophila disc regeneration.The Journal of biological chemistry · 2026Article
- Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.Cell reports · 2026Article
- Timed secreted proteomes reveal regulation of hepatokines by the liver circadian clock.Nature communications · 2026Article
- Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking.Nature communications · 2026Article
- Serpina1e mediates the exercise-induced enhancement of hippocampal memory in male mice.Nature communications · 2026Article
- Exercise pills for cardiometabolic health cannot mimic the exercise milieu.Trends in endocrinology and metabolism: TEM · 2026Review
- Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies.Nature biomedical engineering · 2026Article
- Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).bioRxiv : the preprint server for biology · 2026Article
- Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging.Nature immunology · 2026Article
- Recent Advances in Proximity Labeling-Based Subcellular Proteomic Mapping.Molecular & cellular proteomics : MCP · 2026Review
- Cross-Platform Transcriptomic Analysis of 40 Human and Rodent Skeletal Muscle Exerkines.Muscles (Basel, Switzerland) · 2026Review
- Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle.bioRxiv : the preprint server for biology · 2026Article
- Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
17 authors at 7 institutions in 2 countries.
Wei WeiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Nicholas M RileySarafan ChEM-H, Stanford University, Stanford, CA 94305, USA; Department of Chemistry, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Xuchao LyuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA 94305, USA.
Xiaotao ShenDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA.
Jing GuoDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Steffen H RaunDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Meng ZhaoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Maria Dolores Moya-GarzonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Himanish BasuDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Alan Sheng-Hwa TungDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Veronica L LiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Wentao HuangWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Amanda L WiggenhornDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Katrin J SvenssonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Carolyn R BertozziSarafan ChEM-H, Stanford University, Stanford, CA 94305, USA; Department of Chemistry, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Jonathan Z LongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA 94305, USA. Electronic address: jzlong@stanford.edu.
Stanford University · USCardiovascular Institute of the South · USHoward Hughes Medical Institute · USHarvard University · USStanford Medicine · USUniversity of Copenhagen · DKWhitehead Institute for Biomedical Research · US
Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MStanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5MChemical interrogation of metabolic tissue crosstalkDP1DK130641 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2021 to 2025
$3.9MInvestigating the Surface GlycoproteomeR01CA200423 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2015 to 2026
$3.8MMechanisms controlling fructose uptake and utilizationR01DK125260 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2020 to 2026
$3.5MChemical control of energy metabolism by N-acyl amino acidsR01DK124265 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2020 to 2024
$2.0MThe role of circulating Slit2 in adipose thermogenesis and diabetesR00DK111916 · NIDDK · STANFORD UNIVERSITY · PI SVENSSON, KATRIN JENNIFER · 2018 to 2020
$731kCIRCULATING FACTORS THAT REGULATE BROWN AND BEIGE FATR00DK105203 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2018 to 2020
$728kCirculating Factors that Regulate Brown and Beige FatK99DK105203 · NIDDK · DANA-FARBER CANCER INST · PI LONG, JONATHAN Z · 2015 to 2016
$182kThe role of circulating Slit2 in adipose thermogenesis and diabetesK99DK111916 · NIDDK · DANA-FARBER CANCER INST · PI SVENSSON, KATRIN JENNIFER · 2016 to 2017
$180kCapturing the Holistic Glycocode through Systems GlycobiologyK99GM147304 · NIGMS · STANFORD UNIVERSITY · PI RILEY, NICHOLAS M · 2022 to 2022
$100kNCI NIH HHS R01 CA200423NIDDK NIH HHS DP1 DK130641NIDDK NIH HHS K99 DK105203NIDDK NIH HHS K99 DK111916NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R00 DK105203NIDDK NIH HHS R00 DK111916NIDDK NIH HHS R01 DK124265NIDDK NIH HHS R01 DK125260NIGMS NIH HHS K99 GM147304
Abstract
There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.
Indexed as
Diabetes MellitusSecretomeAnimalsMiceObesityProteinsProteomicsProteinscell typeCES2energy metabolismexerciseexercise performancehepatokineobesitysecretometissue crosstalk
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