Evidence map›Paper›PMID 37141858›Full record

ArticleNeuron2023

An Hspa8 variant is a shocking modifier of spinal muscular atrophy in mice.

Anton James Blatnik, Arthur Harry Macleod Burghes

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. In Search of Spinal Muscular Atrophy Disease Modifiers.International journal of molecular sciences · 2024
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anton James BlatnikDepartment of Biological Chemistry & Pharmacology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address: blatnik.12@osu.edu.
Arthur Harry Macleod BurghesDepartment of Biological Chemistry & Pharmacology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address: burghes.1@osu.edu.
The Ohio State University Wexner Medical Center · US

Funding

Genetic Suppression of SMN Mutations in Spinal Muscular AtrophyR01NS123736 · NINDS · OHIO STATE UNIVERSITY · PI BURGHES, ARTHUR H. M. · 2021 to 2025
$2.5M
NINDS NIH HHS R01 NS123736
6 · The paper itself

Abstract

In this issue of Neuron, Kim et al.

Indexed as

Muscular Atrophy, SpinalAnimalsDisease Models, AnimalHSC70 Heat-Shock ProteinsMiceNeuronsPhenotypeRNA SplicingSurvival of Motor Neuron 1 ProteinHSC70 Heat-Shock ProteinsHspa8 protein, mouseSurvival of Motor Neuron 1 Protein

Identifiers

PMID37141858
OpenAlexW4367840824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.