ReviewDevelopmental cognitive neuroscience2023
Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates.
Review in Developmental cognitive neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fetal brain MRI atlases and datasets: A review.NeuroImage · 2024Pooled it
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- The superior temporal asymmetrical pit remains asymmetric in autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Purkinje cell arrival at the Purkinje cell layer orchestrates cerebellar foliation and its temporal sequence.iScience · 2026Article
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- AI segmentation requires accounting for brain size to maintain performance on developmental MRI cohorts.bioRxiv : the preprint server for biology · 2026Article
- Decoding the origins of cellular self-organization for engineered biology.Nature biotechnology · 2026Review
- Evaluation of a New Paracingulate Sulcus Identification and Measurement Protocol.Human brain mapping · 2026Article
- Antenatal Opioid Exposure and Cerebral Cortical Maturation in Newborns.JAMA network open · 2026Article
- Linking changes in sulcal morphometry to cognitive development from childhood to adolescence.Communications biology · 2026Article
- Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders.Cells · 2026Review
- Alterations in Brain White Matter Tractography in Older Long-Term Breast Cancer Survivors Treated with Chemotherapy.Brain sciences · 2026Article
- Decoding cortical folding with deep learning: toward neurodevelopmental biomarkers of psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure.Communications biology · 2026Article
- Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia.Molecular psychiatry · 2025Review
- Review
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- The Impacts of Enlarged Subarachnoid Space on Brain Growth and Cortex Maturation in Very Preterm Infants.Diagnostics (Basel, Switzerland) · 2025Article
- Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration.Nature communications · 2025Article
- Functional connectivity of the superior temporal sulcus at term-equivalent age: effects of gestational age and sex.Brain structure & function · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The folding of the human brain mostly takes place in utero, making it challenging to study. After a few pioneer studies looking into it in post-mortem foetal specimen, modern approaches based on neuroimaging have allowed the community to investigate the folding process in vivo, its normal progression, its early disturbances, and its relationship to later functional outcomes. In this review article, we aimed to first give an overview of the current hypotheses on the mechanisms governing cortical folding. After describing the methodological difficulties raised by its study in fetuses, neonates and infants with magnetic resonance imaging (MRI), we reported our current understanding of sulcal pattern emergence in the developing brain. We then highlighted the functional relevance of early sulcal development, through recent insights about hemispheric asymmetries and early factors influencing this dynamic such as prematurity. Finally, we outlined how longitudinal studies have started to relate early folding markers and the child's sensorimotor and cognitive outcome. Through this review, we hope to raise awareness on the potential of studying early sulcal patterns both from a fundamental and clinical perspective, as a window into early neurodevelopment and plasticity in relation to growth in utero and postnatal environment of the child.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.