ArticleACS sensors2023
Constant Conversion Rate of Endolysosomes Revealed by a pH-Sensitive Fluorescent Probe.
Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 30 citations in OpenAlex.
- Surface-Enhanced Raman Scattering Imaging of Dynamic pH Changes in Lysosomes during Cancer Cell Invasion on a Microfluidic Chip.Chemical & biomedical imaging · 2026Article
- Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV.Frontiers in pharmacology · 2025Review
- Probing the dynamic crosstalk of lysosomes and mitochondria with structured illumination microscopy.Trends in analytical chemistry : TRAC · 2023Article
- A general design of pyridinium-based fluorescent probes for enhancing two-photon microscopy.Biosensors & bioelectronics · 2023Article
- Quantifying cell viability through organelle ratiometric probing.Chemical science · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Endolysosome dynamics plays an important role in autophagosome biogenesis. Hence, imaging the subcellular dynamics of endolysosomes using high-resolution fluorescent imaging techniques would deepen our understanding of autophagy and benefit the development of pharmaceuticals against endosome-related diseases. Taking advantage of the intramolecular charge-transfer mechanism, herein we report a cationic quinolinium-based fluorescent probe (PyQPMe) that exhibits excellent pH-sensitive fluorescence in endolysosomes at different stages of interest. A systematic photophysical and computational study on PyQPMe was carried out to rationalize its highly pH-dependent absorption and emission spectra. The large Stokes shift and strong fluorescence intensity of PyQPMe can effectively reduce the background noise caused by excitation light and microenvironments and provide a high signal-to-noise ratio for high-resolution imaging of endolysosomes. By applying PyQPMe as a small molecular probe in live cells, we were able to reveal a constant conversion rate from early endosomes to late endosomes/lysosomes during autophagy at the submicron level.
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Registered trials
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