Evidence map›Paper›PMID 37141415›Full record

ArticleOncotarget2023

Targeting cellular respiration as a therapeutic strategy in glioblastoma.

Enyuan Shang, Trang Thi Thu Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D Siegelin

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4International journal of molecular sciences · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Enyuan ShangDepartment of Biological Sciences, Bronx Community College, City University of New York, NY 10453, USA.
Trang Thi Thu NguyenDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Mike-Andrew WesthoffDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm 89081, Germany.
Georg Karpel-MasslerDepartment of Neurosurgery, Ulm University Medical Center, Ulm 89081, Germany.
Markus D SiegelinDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Universität Ulm · DECity University of New York · USColumbia University Irving Medical Center · US

Funding

HDAC Inhibitors Reverse the Warburg Effect and Elicit Metabolic Vulnerabilities in Model Systems of GlioblastomaR01NS113793 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SIEGELIN, MARKUS D · 2021 to 2025
$2.0M
Targeting Mutant IDH1 for a Novel Synthetic Lethal Interaction in Malignant GliomasR01NS102366 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SIEGELIN, MARKUS D · 2018 to 2022
$1.8M
NINDS NIH HHS R01 NS102366NINDS NIH HHS R01 NS113793
6 · The paper itself

Abstract

While glycolysis is abundant in malignancies, mitochondrial metabolism is significant as well. Mitochondria harbor the enzymes relevant for cellular respiration, which is a critical pathway for both regeneration of reduction equivalents and energy production in the form of ATP. The oxidation of NADH

Indexed as

GlioblastomaCell RespirationCitric Acid CycleEnergy MetabolismGlucoseGlycolysisHumansNADOxidoreductasesGlucoseNADOxidoreductasescarbon tracingcentral carbon metabolismglioblastomalactatemetabolism

Identifiers

PMID37141415
PMCPMC10159369
OpenAlexW4372334636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.