ArticleScience (New York, N.Y.)2023
De novo phytosterol synthesis in animals.
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Mapping molluscan endocrinology: a systematic and critical appraisal.Biological reviews of the Cambridge Philosophical Society · 2026Pooled it
- Animal degradation of microbial storage polyhydroxyalkanoates.Nature ecology & evolution · 2026Article
- Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Differentiation of Plant and Animal-Derived Cholesterol Using irm-Magnetic resonance in chemistry : MRC · 2026Article
- The potential of metabolic engineering for sustainable phytosterol production.Advanced biotechnology · 2026Review
- A plant-specific cytochromeScience advances · 2025Article
- The C24-methyl/ethyl sterol ratio is increased by Rhizophagus irregularis colonization.Mycorrhiza · 2025Article
- Production, Transport, Fate and Effects of Lipids in the Marine Environment.Marine drugs · 2025Review
- Cholesterol and sterols in molluscan endocrinology: past, present, future.Frontiers in endocrinology · 2025Review
- Health interest of cholesterol and phytosterols and their contribution to one health approach: Review.Heliyon · 2024Review
- Comprehensive Review on Plant Cytochrome P450 Evolution: Copy Number, Diversity, and Motif Analysis From Chlorophyta to Dicotyledoneae.Genome biology and evolution · 2024Review
- Research Progress on the Quality, Extraction Technology, Food Application, and Physiological Function of Rice Bran Oil.Foods (Basel, Switzerland) · 2024Review
- Proterozoic microfossils continue to provide new insights into the rise of complex eukaryotic life.Royal Society open science · 2024Review
- Common origin of sterol biosynthesis points to a feeding strategy shift in Neoproterozoic animals.Nature communications · 2023Article
- Article
- Sterol methyltransferases in uncultured bacteria complicate eukaryotic biomarker interpretations.Nature communications · 2023Article
- Lipid and glucose metabolism in senescence.Frontiers in nutrition · 2023Review
- DefectiveGut microbesArticle
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Sterols are vital for nearly all eukaryotes. Their distribution differs in plants and animals, with phytosterols commonly found in plants whereas most animals are dominated by cholesterol. We show that sitosterol, a common sterol of plants, is the most abundant sterol in gutless marine annelids. Using multiomics, metabolite imaging, heterologous gene expression, and enzyme assays, we show that these animals synthesize sitosterol de novo using a noncanonical C-24 sterol methyltransferase (C
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.