Evidence map›Paper›PMID 37141291›Full record

ArticlePloS one2023

Role of intrapulmonary lymph nodes in patients with NSCLC and visceral pleural invasion. The VPI 1314 multicenter registry study protocol.

Fabrizio Minervini, Peter Kestenholz, Pietro Bertoglio, Allen Li, Henning Nilius

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05596578 (Role of Intrapulmonary Lymph Nodes in Patients With NSCLC and Visceral Pleural Invasion), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05596578 recruitingnot on this map

Role of Intrapulmonary Lymph Nodes in Patients With NSCLC and Visceral Pleural Invasion

TypeobservationalSponsorLuzerner KantonsspitalRan2023 to 2029Enrolled958ConditionsLung Cancer, Lymph Node Metastasis
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Fabrizio MinerviniDivision of Thoracic Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland.ORCID 0000-0003-3595-7307
Peter KestenholzDivision of Thoracic Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Pietro BertoglioDivision of Thoracic Surgery, IRCSS Azienda Ospedaliero-Universitaria, Bologna, Italy.ORCID 0000-0002-6267-0099
Allen LiThe Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Henning NiliusDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland.
University of Lucerne · CHAzienda USL di Bologna · ITOttawa Hospital · CAUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the lung cancer classification (TNM), the involvement of thoracic lymph nodes is relevant from a diagnostic and prognostic point of view. Even if imaging modality could help in selecting patients who should undergo surgery, a systematic lymph node dissection during lung surgery is mandatory to identify the subgroup of patients who can benefit from an adjuvant treatment.

methodsPatients undergoing elective lobectomy/bilobectomy/segmentectomy) for non-small cell lung cancer and lymphadenectomy with lymph nodes station 10-11-12-13-14 sampling that meet the inclusion and exclusion criteria will be recorded in a multicenter prospective database. The overall incidence of N1 patients (subclassified in: Hilar Lymph nodes, Lobar Lymph nodes and Sublobar Lymph nodes) will be examined as well as the incidence of visceral pleural invasion. DISCUSSION: The aim of this multicenter prospective study is to evaluate the incidence of intrapulmonary lymph nodes metastases and the possible relation with visceral pleural invasion. Identifying patients with lymph node station 13 and 14 metastases and/or a link between visceral pleural invasion and presence of micro/macro metastases in intrapulmonary lymph nodes may have an impact on decision-making process.

trial registrationClinicalTrials.gov ID: NCT05596578.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsHumansLungLymphatic MetastasisLymph Node ExcisionLymph NodesMulticenter Studies as TopicNeoplasm StagingPneumonectomyPrognosisProspective StudiesRegistriesRetrospective Studies

Identifiers

PMID37141291
PMCPMC10159114
OpenAlexW4368357118

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.