ArticleBrain : a journal of neurology2023
Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission.
Article in Brain : a journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Neuromodulation of the central nervous system for facial pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Dopamine in Tourette syndrome: a 30-year bibliometric analysis of hotspot evolution.Frontiers in neurology · 2025Pooled it
- Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia.The Journal of clinical investigation · 2026Article
- Flexible Multimodal Neural Probe with Integrated Three-Electrode Aptameric Sensing for In Vivo Monitoring of Dopamine Dynamics and Neural Activity.ACS chemical neuroscience · 2026Article
- What factors influence the length of stay and readmission after deep brain stimulation surgery? a tertiary centre study.Acta neurochirurgica · 2026Article
- No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View.Neurology international · 2026Review
- Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.medRxiv : the preprint server for health sciences · 2026Article
- Tics severity in Tourette syndrome associated with higher glutamatergic activity in the anterior cingulate cortex.Brain communications · 2026Article
- Metabolic abnormalities of the cortico‑striato‑thalamo‑cortical circuit of rats with tic disorder.Molecular medicine reports · 2025Article
- Frequent vocalizations and deep brain stimulation-responsive hyperkinesia in a striatal disinhibition rat model for Tourette syndrome.The international journal of neuropsychopharmacology · 2025Article
- Serum iron status and risk of Tourette's syndrome: a Mendelian randomization study.European journal of pediatrics · 2025Article
- Deep brain stimulation (DBS) in movement disorders management: exploring therapeutic efficacy, neurobiological mechanisms, and clinical implications.Annals of medicine and surgery (2012) · 2025Review
- Article
- Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders.Frontiers in pediatrics · 2025Review
- Thalamic Volumes and Functional Networks Linked With Self-Regulation Dysfunction in Major Depressive Disorder.CNS neuroscience & therapeutics · 2024Article
- Deep brain stimulation for Tourette's syndrome.Neurosurgical review · 2024Review
- Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning.Molecular psychiatry · 2024Article
- Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024Article
- Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry.ACS omega · 2024Article
- Efficacy of cognitive-behavioral therapy combined with habit reversal training on anxiety disorders in children with Tourette's syndrome.World journal of psychiatry · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Tourette syndrome is a childhood-onset neuropsychiatric disorder characterized by intrusive motor and vocal tics that can lead to self-injury and deleterious mental health complications. While dysfunction in striatal dopamine neurotransmission has been proposed to underlie tic behaviour, evidence is scarce and inconclusive. Deep brain stimulation (DBS) of the thalamic centromedian parafascicular complex (CMPf), an approved surgical interventive treatment for medical refractory Tourette syndrome, may reduce tics by affecting striatal dopamine release. Here, we use electrophysiology, electrochemistry, optogenetics, pharmacological treatments and behavioural measurements to mechanistically examine how thalamic DBS modulates synaptic and tonic dopamine activity in the dorsomedial striatum. Previous studies demonstrated focal disruption of GABAergic transmission in the dorsolateral striatum of rats led to repetitive motor tics recapitulating the major symptom of Tourette syndrome. We employed this model under light anaesthesia and found CMPf DBS evoked synaptic dopamine release and elevated tonic dopamine levels via striatal cholinergic interneurons while concomitantly reducing motor tic behaviour. The improvement in tic behaviour was found to be mediated by D2 receptor activation as blocking this receptor prevented the therapeutic response. Our results demonstrate that release of striatal dopamine mediates the therapeutic effects of CMPf DBS and points to striatal dopamine dysfunction as a driver for motor tics in the pathoneurophysiology of Tourette syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.