Evidence map›Paper›PMID 37141237›Full record

ArticlePloS one2023

Assessment of remote ischemic conditioning delivery with optical sensor in acute ischemic stroke: Randomised clinical trial protocol.

Radhika Nair, Robert Sarmiento, Asif Sheriff, Ashfaq Shuaib, Brian Buck, Michel Gauthier, Vivian Mushahwar, Martin Ferguson-Pell, Mahesh Kate

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05408130 (Remote Ischemic Conditioning With Novel Optical Sensor Feedback Device in Acute Ischemic Stroke), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05408130 nacompletednot on this map

Remote Ischemic Conditioning With Novel Optical Sensor Feedback Device in Acute Ischemic Stroke

TypeinterventionalSponsorUniversity of AlbertaRan2022 to 2024Enrolled51ConditionsStroke, Acute Ischemic, Small Vessel Cerebrovascular DiseaseArmsRemote Ischemic Conditioning with Novel Optical Sensor Feedback Device, Sham Remote Ischemic Conditioning with Novel Optical Sensor Feedback Device
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Radhika NairDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-1404-4496
Robert SarmientoDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-7708-1804
Asif SheriffDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Ashfaq ShuaibDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Brian BuckDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Michel GauthierDepartment of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.
Vivian MushahwarDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Martin Ferguson-PellDepartment of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.
Mahesh KateDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-4794-2882
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRemote ischemic conditioning (RIC) is delivered by a blood pressure cuff over the limb, raising pressure 50 mmHg above the systolic blood pressure, to a maximum of 200 mmHg. The cuff is inflated for five minutes and then deflated for five minutes in a sequential ischemia-reperfusion cycle 4-5 times per session. Elevated pressure in the limb may be associated with discomfort and consequently reduced compliance. Continuous assessment of relative blood concentration and oxygenation with a tissue reflectance spectroscopy (a type of optical sensor device) placed over the forearm during the RIC sessions of the arm will allow us to observe the effect of inflation and deflation of the pressure cuff. We hypothesize, in patients with acute ischemic stroke (AIS) and small vessel disease, RIC delivered together with a tissue reflectance sensor will be feasible.

methodsThe study is a prospective, single-center, randomized control trial testing the feasibility of the device. Patients with AIS within 7 days from symptoms onset; who also have small vessel disease will be randomized 2:1 to intervention or sham control arms. All patients randomized to the intervention arm will receive 5 cycles of ischemia/reperfusion in the non-paralyzed upper limb with a tissue reflectance sensor and patients in the sham control arm will receive pressure by keeping the cuff pressure at 30 mmHg for 5 minutes. A total of 51 patients will be randomized, 17 in the sham control arm and 34 in the intervention arm. The primary outcome measure will be the feasibility of RIC delivered for 7 days or at the time of discharge. The secondary device-related outcome measures are fidelity of RIC delivery and the completion rate of intervention. The secondary clinical outcome includes a modified Rankin scale, recurrent stroke and cognitive assessment at 90 days. DISCUSSION: RIC delivery together with a tissue reflectance sensor will allow insight into the blood concentration and blood oxygenation changes in the skin. This will allow individualized delivery of the RIC and improve compliance. CLINICAL

trial registrationClinicalTrials.gov Identifier: NCT05408130, June 7, 2022.

Indexed as

Ischemic StrokeStrokeHumansIschemiaProspective StudiesRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID37141237
PMCPMC10159200
OpenAlexW4368361186

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.