Evidence map›Paper›PMID 37141191›Full record

ArticlePLoS biology2023

An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.

Chengliang Wang, Jianbin Ruan

Open access · goldAbstract readComment
In one paragraph

Article in PLoS biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. [Amentoflavone alleviates acute lung injury in mice by inhibiting cell pyroptosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chengliang WangDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, United States of America.
Jianbin RuanDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, United States of America.ORCID 0000-0001-5843-8273
UConn Health · US

Funding

Structural and mechanistic elucidation of non-canonical inflammasome signalingR01AI158435 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RUAN, JIANBIN · 2021 to 2025
$2.0M
NIAID NIH HHS R01 AI158435
6 · The paper itself

Abstract

The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation and divergence of gasdermin E.

Indexed as

LanceletsPyroptosisAnimalsDefense MechanismsGasderminsNeoplasm ProteinsGasderminsNeoplasm Proteins

Identifiers

PMID37141191
PMCPMC10159131
OpenAlexW4368356204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.