Evidence map›Paper›PMID 37141147›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease.

Eden A Houske, Matthew G Glimm, Annika R Bergstrom, Sally K Slipher, Hope D Welhaven, Mark C Greenwood, Greta M Linse, Ronald K June, Alan S L Yu, Darren P Wallace and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Eden A HouskeDepartment of Biological and Environmental Science, Carroll College, Helena, Montana, United States.ORCID 0000-0002-1439-4085
Matthew G GlimmDepartment of Biological and Environmental Science, Carroll College, Helena, Montana, United States.
Annika R BergstromDepartment of Chemical and Biological Engineering, Villanova University, Villanova, Pennsylvania, United States.ORCID 0000-0002-1775-092X
Sally K SlipherDepartment of Mathematical Sciences, Montana State University, Bozeman, Montana, United States.
Hope D WelhavenDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, United States.ORCID 0000-0001-9330-6903
Mark C GreenwoodDepartment of Mathematical Sciences, Montana State University, Bozeman, Montana, United States.ORCID 0000-0001-6933-1201
Greta M LinseDepartment of Mathematical Sciences, Montana State University, Bozeman, Montana, United States.ORCID 0000-0002-7823-7716
Ronald K JuneDepartment of Mechanical and Industrial Engineering, Montana State University, Bozeman, Montana, United States.ORCID 0000-0003-0752-4109
Alan S L YuDepartment of Internal Medicine, Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0002-1776-2533
Darren P WallaceDepartment of Internal Medicine, Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0003-4616-7669
Alyssa K HahnDepartment of Biological and Environmental Science, Carroll College, Helena, Montana, United States.ORCID 0000-0002-8884-2610
Montana State University · USCarroll College · USUniversity of Kansas Medical Center · USVillanova University · US

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Diane E Mahoney · 2019 to 2026
$21.5M
Polycystin Function Resource Development CoreU54DK126126 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Alan S Yu · 2020 to 2026
$5.8M
Role of Glucose metabolism in Chondrocyte MechanotransductionR01AR073964 · NIAMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI JUNE, RONALD KENT · 2019 to 2024
$2.4M
NIAMS NIH HHS R01 AR073964NIDDK NIH HHS U54 DK126126NIGMS NIH HHS P20 GM103474NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of numerous fluid-filled cysts that lead to progressive loss of functional nephrons. Currently, there is an unmet need for diagnostic and prognostic indicators of early stages of the disease. Metabolites were extracted from the urine of patients with early-stage ADPKD (

Indexed as

Polycystic Kidney, Autosomal DominantAmino AcidsAndrogensBetaineBiomarkersCholineDisease ProgressionFatty AcidsHumansMetabolic Networks and PathwaysMetabolomicsSteroidsAmino AcidsAndrogensBetainebetaine aldehydeBiomarkersCholineFatty AcidsSteroidsbiomarkersliquid chromatography-mass spectrometrymetabolomicspolycystic kidney diseaseurine

Identifiers

PMID37141147
PMCPMC10281782
OpenAlexW4368359876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.