Evidence map›Paper›PMID 37140829›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort.

Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Claudio Liguori, Francesco Famà, Andrea Donniaquio and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Targeting TMEM175 in Lysosomal Physiology and Human Diseases.Current stem cell research & therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 3 countries.

Beatrice OrsoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy. beatrice27orso@gmail.com.ORCID http://orcid.org/0000-0001-9983-7940
Pietro MattioliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy.
Eun-Jin YoonMemory Network Medical Research Center, Seoul National University, Seoul, South Korea.
Yu Kyeong KimDepartment of Nuclear Medicine, Seoul National University College of Medicine and Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
Heejung KimDepartment of Nuclear Medicine, Seoul National University College of Medicine and Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
Jung Hwan ShinDepartment of Neurology, Seoul National University College of Medicine, Seoul, South Korea.
Ryul KimDepartment of Neurology, Inha University Hospital, Incheon, South Korea.
Claudio LiguoriDepartment of Systems Medicine, University of Rome 'Tor Vergata", Rome, Italy.
Francesco FamàDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy.
Andrea DonniaquioDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy.
Federico MassaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy.
David Vállez GarcíaDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Location VuMC, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Sanne K MelesDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Klaus L LeendersDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Agostino ChiaravallotiIRCCS Neuromed, Pozzilli, Italy.
Matteo PardiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy.
Matteo BaucknehtIRCCS Ospedale Policlinico S. Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Silvia MorbelliIRCCS Ospedale Policlinico S. Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Flavio NobiliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy.
Jee-Young LeeDepartment of Neurology, Seoul National University College of Medicine and Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
Dario ArnaldiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Largo Daneo 3, 16132, Genoa, Italy.
Ospedale Policlinico San Martino · ITSeoul National University · KRUniversity of Genoa · ITUniversity Medical Center Groningen · NLUniversity of Rome Tor Vergata · ITAmsterdam Neuroscience · NLInha University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA brain glucose metabolism pattern related to phenoconversion in patients with idiopathic/isolated REM sleep behaviour disorder (iRBDconvRP) was recently identified. However, the validation of the iRBDconvRP in an external, independent group of iRBD patients is needed to verify the reproducibility of such pattern, so to increase its importance in clinical and research settings. The aim of this work was to validate the iRBDconvRP in an independent group of iRBD patients.

methodsForty iRBD patients (70 ± 5.59 years, 19 females) underwent brain [

resultsThe iRBDconvRP significantly discriminated converters from non-converters iRBD patients (p = 0.016; Area under the Curve 0.74, Sensitivity 0.69, Specificity 0.78), and it significantly predicted phenoconversion (Hazard ratio 4.26, C.I.95%: 1.18-15.39).

conclusionsThe iRBDconvRP confirmed its robustness in predicting phenoconversion in an independent group of iRBD patients, suggesting its potential role as a stratification biomarker for disease-modifying trials.

Indexed as

Parkinson DiseaseParkinsonian DisordersREM Sleep Behavior DisorderBrainFemaleHumansReproducibility of Results[18F]FDG-PETAlpha-synucleinopathiesBrain metabolic patternDementia with Lewy bodiesParkinson’s diseaseREM behaviour disorder

Identifiers

PMID37140829
PMCPMC10415520
OpenAlexW4368357877

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.