Evidence map›Paper›PMID 37140823›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2023

Safety and efficacy of new potassium binders on hyperkalemia management in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials.

Pedro E P Carvalho, Thiago M A Veiga, Henrique Lacerda, Matheus R Tofanelli, Douglas M Gewehr, Maria C P Nunes, Ana C Simões E Silva

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Heart failure burden and care among cardiology inpatients: insights from the Hellenic Cardiorenal Morbidity Snapshot (HECMOS) study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  3. Article
  4. Article
  5. Effect of eplerenone in acute heart failure using a win ratio approach.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Pedro E P CarvalhoDepartment of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.ORCID http://orcid.org/0000-0002-0918-6759
Thiago M A VeigaDepartment of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Henrique LacerdaDepartment of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Matheus R TofanelliDepartment of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Douglas M GewehrCuritiba Heart Institute (INCOR Curitiba), Curitiba, Paraná, Brazil.
Maria C P NunesDepartment of Internal Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Ana C Simões E SilvaDepartment of Pediatrics, Unit of Pediatric Nephrology, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, UFMG, Research Level ID of CNPq, Alfredo Balena Avenue, 190, 2nd Floor, Room #281, Belo Horizonte, MG, 30130-100, Brazil. acssilva@hotmail.com.ORCID http://orcid.org/0000-0001-9222-3882
Universidade Federal de Minas Gerais · BRInstituto de Neurologia de Curitiba · BRNational Council for Scientific and Technological Development · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperkalemia leads to suboptimal use of evidence-based therapies in patients with heart failure (HF). Therefore, we aimed to assess whether new potassium binders are effective and safe to promote medical optimization in patients with HF.

methodsMEDLINE, Cochrane, and Embase were searched for randomized controlled trials (RCTs) that reported outcomes after initiation of Patiromer or Sodium Zirconium Cyclosilicate (SZC) versus placebo in patients with HF at high risk of hyperkalemia development. Risk ratios (RR) with 95% confidence intervals (CI) were pooled with a random effects model. Quality assessment and risk of bias were performed according to Cochrane recommendations.

resultsA total of 1432 patients from 6 RCTs were included, of whom 737 (51.5%) patients received potassium binders. In patients with HF, potassium binders increased the use of renin-angiotensin-aldosterone inhibitors (RR 1.14; 95% CI 1.02-1.28; p = 0.021; I

conclusionThe use of new potassium binders Patiromer or SZC in patients with HF at risk for hyperkalemia increased the rates of medical therapy optimization with renin-angiotensin-aldosterone inhibitors and reduced the incidence of hyperkalemia, at the cost of an increased prevalence of hypokalemia.

Indexed as

Heart FailureHyperkalemiaHypokalemiaAldosteroneAngiotensinsHumansMineralocorticoid Receptor AntagonistsPotassiumRandomized Controlled Trials as TopicReninRenin-Angiotensin SystemSilicatesAldosteroneAngiotensinsMineralocorticoid Receptor AntagonistsPotassiumReninSilicatessodium zirconium cyclosilicateHeart failureHyperkalemiaPatiromerPotassium bindersSzc

Identifiers

PMID37140823
OpenAlexW4368356343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.