Evidence map›Paper›PMID 37140805›Full record

ArticleJournal of thrombosis and thrombolysis2023

CT imaging determinants of persistent hypoxemia in acute intermediate-risk pulmonary embolism.

Syed Moin Hassan, Pietro Nardelli, Jasleen K Minhas, Samuel Y Ash, Rubén San José Estépar, MaryEllen C Antkowiak, Jessica B Badlam, Gregory Piazza, Raúl San José Estépar, George R Washko and 1 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06310018 (A Prospective, Single-Arm, Multicenter Study of Augmented Ultrasound-Facilitated, Catheter-Directed Low-Dose Fibrinolysis for Pulmonary Embolism), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06310018 suspendednot on this mapstarted 2027, after this paper: background citation

A Prospective, Single-Arm, Multicenter Study of Augmented Ultrasound-Facilitated, Catheter-Directed Low-Dose Fibrinolysis for Pulmonary Embolism (SONIC-PE)

Typeobservational_patient_registrySponsorBrigham and Women's HospitalRan2027 to 2028Enrolled60ConditionsPulmonary Embolism, Right Ventricular Dysfunction, Right Ventricular FailureArmsUltrasound-facilitated, catheter-directed lower-dose fibrinolysis, Tissue Plasminogen Activator
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Syed Moin HassanDivision of Pulmonary Disease and Critical Care Medicine, University of Vermont, Burlington, VT, USA. syedmoin.hassan@uvmhealth.org.ORCID http://orcid.org/0000-0002-1544-3280
Pietro NardelliDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jasleen K MinhasDivision of Pulmonary, Allergy and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
Samuel Y AshDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rubén San José EstéparDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
MaryEllen C AntkowiakDivision of Pulmonary Disease and Critical Care Medicine, University of Vermont, Burlington, VT, USA.
Jessica B BadlamDivision of Pulmonary Disease and Critical Care Medicine, University of Vermont, Burlington, VT, USA.
Gregory PiazzaDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Raúl San José EstéparDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
George R WashkoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Farbod N RahaghiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Brigham and Women's Hospital · USUniversity of Vermont · USUniversity of Pennsylvania · US

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
Classification and Prognostication in Pulmonary Thromboembolism Using Computed Tomography Image AnalyticsR01HL164717 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Farbod Nicholas Rahaghi · 2022 to 2026
$3.6M
Airway Inspector: a chest imaging biomarker software platform for COPDR01HL116931 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2013 to 2017
$2.2M
NHLBI NIH HHS 1R01HL116931NHLBI NIH HHS 1R01HL164717-01NHLBI NIH HHS T32-HL-007891
6 · The paper itself

Abstract

The factors associated with persistent hypoxemia after pulmonary embolus (PE) are not well understood. Predicting the need for oxygen post discharge at the time of diagnosis using available CT imaging will enable better discharge planning. To examine the relationship between CT derived imaging markers (automated computation of arterial small vessel fraction, pulmonary artery diameter to aortic diameter ratio (PA:A), right to left ventricular diameter ratio (RV:LV) and new oxygen requirement at the time of discharge in patients diagnosed with acute intermediate-risk PE. CT measurements were obtained in a retrospective cohort of patients with acute-intermediate risk PE admitted to Brigham and Women's Hospital between 2009 and 2017. Twenty one patients without a history of lung disease requiring home oxygen and 682 patients without discharge oxygen requirements were identified. There was an increased median PA:A ratio (0.98 vs. 0.92, p = 0.02) and arterial small vessel fraction (0.32 vs. 0.39, p = 0.001) in the oxygen-requiring group], but no difference in the median RV:LV ratio (1.20 vs. 1.20, p = 0.74). Being in the upper quantile for the arterial small vessel fraction was associated with decreased odds of oxygen requirement (OR 0.30 [0.10-0.78], p = 0.02). Loss of arterial small vessel volume as measured by arterial small vessel fraction and an increase in the PA:A ratio at the time of diagnosis were associated with the presence of persistent hypoxemia on discharge in acute intermediate-risk PE.

Indexed as

Pulmonary EmbolismVentricular Dysfunction, RightAcute DiseaseAftercareFemaleHumansHypoxiaOxygenPatient DischargePredictive Value of TestsRetrospective StudiesTomography, X-Ray ComputedOxygenAcute pulmonary embolismHypoxemiaPE prognosticationPersistent hypoxemiaRight ventricular dysfunctionVascular pruningVascular reconstructions

Identifiers

PMID37140805
OpenAlexW4368360638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.