Evidence map›Paper›PMID 37140682›Full record

ArticleInflammation2023

Aryl-functionalised α,α'-Trehalose 6,6'-Glycolipid Induces Mincle-independent Pyroptotic Cell Death.

Kristel Kodar, Emma M Dangerfield, Amy J Foster, Devlin Forsythe, Shigenari Ishizuka, Melanie J McConnell, Sho Yamasaki, Mattie S M Timmer, Bridget L Stocker

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Kristel KodarSchool of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
Emma M DangerfieldSchool of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
Amy J FosterSchool of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
Devlin ForsytheCentre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
Shigenari IshizukaDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Melanie J McConnellCentre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
Sho YamasakiDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Mattie S M TimmerSchool of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand. mattie.timmer@vuw.ac.nz.
Bridget L StockerSchool of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand. bridget.stocker@vuw.ac.nz.
Victoria University of Wellington · NZChiba University · JPOsaka University · JPStatistics New Zealand · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α,α'-Trehalose 6,6'-glycolipids have long been known for their immunostimulatory properties. The adjuvanticity of α,α'-trehalose 6,6'-glycolipids is mediated by signalling through the macrophage inducible C-type lectin (Mincle) and the induction of an inflammatory response. Herein, we present an aryl-functionalised trehalose glycolipid, AF-2, that leads to the release of cytokines and chemokines, including IL-6, MIP-2 and TNF-α, in a Mincle-dependent manner. Furthermore, plate-coated AF-2 also leads to the Mincle-independent production of IL-1β, which is unprecedented for this class of glycolipid. Upon investigation into the mode of action of plate-coated AF-2, it was observed that the treatment of WT and Mincle

Indexed as

GlycolipidsPyroptosisAnimalsFurylfuramideHumansLectins, C-TypeMiceNLR Family, Pyrin Domain-Containing 3 ProteinTrehaloseFurylfuramideGlycolipidsLectins, C-TypeNLR Family, Pyrin Domain-Containing 3 ProteinTrehaloseadjuvantCaspase-1.inflammasomemacrophageminclepyroptosis

Identifiers

PMID37140682
PMCPMC10359228
OpenAlexW4368361834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.