Evidence map›Paper›PMID 37140468›Full record

ArticleAIDS research and human retroviruses2023

Obesity Modifies the Relationship Between Raltegravir and Dolutegravir Hair Concentrations and Body Weight Gain in Women Living with HIV.

Cecile D Lahiri, C Christina Mehta, Craig Sykes, Sheri D Weiser, Frank Palella, Jordan E Lake, John W Mellors, Deborah Gustafson, Audrey L French, Adaora A Adimora and 9 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. The miRNomics of antiretroviral therapy-induced obesity.Functional & integrative genomics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 1 country.

Cecile D LahiriDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
C Christina MehtaDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Craig SykesClinical Pharmacology and Analytical Chemistry Core, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
Sheri D WeiserDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA.
Frank PalellaDivision of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Chicago, Illinois, USA.
Jordan E LakeDivision of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
John W MellorsDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Deborah GustafsonDepartment of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Audrey L FrenchDivision of Infectious Diseases, CORE Center/Stroger (Cook County) Hospital, Chicago, Illinois, USA.
Adaora A AdimoraDivision of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Deborah Konkle-ParkerDivision of Infectious Diseases, Department of Medicine, University of Mississippi School of Medicine, Jackson, Mississippi, USA.
Anjali SharmaDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Hector BolivarDivision of Infectious Diseases, Department of Medicine, University of Miami Health System, Miami, Florida, USA.
Seble G KassayeDivision of Infectious Diseases, Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA.
Leah H RubinDepartments of Neurology, Psychiatry and Behavioral Sciences, and Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jessica A AlvarezDivision of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Elizabeth T GolubDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Igho OfotokunDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Anandi N ShethDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · USUniversity of North Carolina at Chapel Hill · USAlbert Einstein College of Medicine · USBehavioral Pharma (United States) · USGeorgetown University · USJohn H. Stroger, Jr. Hospital of Cook County · USJohns Hopkins University · USNorthwestern University · USState University of New York · USThe University of Texas Health Science Center at Houston · USUniversity of California System · USUniversity of Miami Health System · USUniversity of Mississippi · USUniversity of Pittsburgh · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS ResearchU01HL146240 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Frank J Palella, Valentina Stosor · 2019 to 2026
$31.5M
MACS/WIHS Combined Cohort Study Clinical Research SiteU01HL146241 · NHLBI · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Anandi Nayan Sheth · 2019 to 2026
$24.2M
MWCCS: Brooklyn Clinical Research SiteU01HL146202 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI TRACEY ELIZABETH WILSON, Jessica Eve Yager · 2019 to 2026
$23.6M
MWCCS: The Chicago Cook County Clinical Research SiteU01HL146245 · NHLBI · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI Audrey French, Ryan Dee Ross · 2019 to 2026
$23.3M
Emory WIHS CRS - Longitudinal CohortU01AI103408 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WINGOOD, GINA MARIA · 2013 to 2018
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Vasiliki Michopoulos · 2018 to 2026
$12.2M
SPPACE INSTI Study: Sex-specific Predictors, Pathways, And Cardiometabolic Effects of Weight Gain Associated with Integrase Strand-Transfer InhibitorsR01DK125246 · NIDDK · EMORY UNIVERSITY · PI ALVAREZ, JESSICA ALEJANDRA, LAHIRI, CECILE DELILLE · 2021 to 2025
$4.2M
Emory University BIRCWH ProgramK12AR084234 · NIAMS · EMORY UNIVERSITY · PI Vasiliki Michopoulos, CLAIRE E STERK · 2024 to 2026
$2.6M
Defining Antiretroviral Pharmacology Within HIV-1 Reservoirs of Males and FemalesK23AI124913 · NIAID · EMORY UNIVERSITY · PI LAHIRI, CECILE DELILLE · 2016 to 2020
$943k
NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146245NIAID NIH HHS K23 AI124913NIAID NIH HHS P30 AI050410NIAID NIH HHS U01 AI103408NIAMS NIH HHS K12 AR084234NIA NIH HHS U54 AG062334NIDDK NIH HHS R01 DK125246
6 · The paper itself

Abstract

Integrase strand-transfer inhibitors (INSTIs) are associated with weight gain in women living with HIV (WLH). Relationships between drug exposure, baseline obesity, and INSTI-associated weight gain remain unclear. Data from 2006 to 2016 were analyzed from virally suppressed WLH enrolled in the Women's Interagency HIV Study, who switched/added an INSTI to antiretroviral therapy: [raltegravir (RAL), dolutegravir (DTG), or elvitegravir (EVG)]. Percent body weight change was calculated from weights obtained a median 6 months pre-INSTI and 14 months post-INSTI initiation. Hair concentrations were measured with validated liquid chromatography-mass spectrometry (MS)/MS assays. Baseline (preswitch) weight status evaluated obese (body mass index, BMI, ≥30 kg/m

Indexed as

HIV-1HIV InfectionsHIV IntegraseHIV Integrase InhibitorsDolutegravirFemaleHeterocyclic Compounds, 3-RingHumansMiddle AgedObesityOxazinesRaltegravir PotassiumWeight GainDolutegravirHeterocyclic Compounds, 3-RingHIV IntegraseHIV Integrase InhibitorsOxazinesRaltegravir PotassiumHIVintegrase inhibitorspharmacologyweight gainwomen

Identifiers

PMID37140468
PMCPMC10712367
OpenAlexW4368360406

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.