Evidence map›Paper›PMID 37140437›Full record

ArticleACS chemical biology2023

Controlled Protein Activities with Viral Proteases, Antiviral Peptides, and Antiviral Drugs.

Elliot P Tague, Jeffrey B McMahan, Nathan Tague, Mary J Dunlop, John T Ngo

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Turn-On Protein Switches for Controlling Actin Binding in Cells.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elliot P TagueDepartment of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-7129-5913
Jeffrey B McMahanDepartment of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0001-5845-605X
Nathan TagueDepartment of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-8114-6700
Mary J DunlopDepartment of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-9261-8216
John T NgoDepartment of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0003-3508-1915
Boston University · US

Funding

Feedback and Noise in a Multiple Antibiotic Resistance CircuitR01AI102922 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Mary J. Dunlop · 2014 to 2026
$4.7M
Translational Research in BiomaterialsT32EB006359 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Michelle H Teplensky · 2009 to 2026
$4.2M
Integrative Approaches for Probing Cell Mechanotransduction in Health and DiseaseR35GM128859 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI John Tuan Ngo · 2018 to 2026
$3.3M
Notch signaling and adhesion regulationR01HL147585 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, CHRISTOPHER S · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL147585NIAID NIH HHS R01 AI102922NIBIB NIH HHS T32 EB006359NIGMS NIH HHS R35 GM128859
6 · The paper itself

Abstract

Chemical control of protein activity is a powerful tool for scientific study, synthetic biology, and cell therapy; however, for broad use, effective chemical inducer systems must minimally crosstalk with endogenous processes and exhibit desirable drug delivery properties. Accordingly, the drug-controllable proteolytic activity of hepatitis C

Indexed as

Antiviral AgentsViral ProteasesDEAD-box RNA HelicasesHepacivirusNucleoside-TriphosphatasePeptide HydrolasesPeptidesProtease InhibitorsSerine EndopeptidasesViral Nonstructural ProteinsAntiviral AgentsDEAD-box RNA HelicasesNS3 protein, hepatitis C virusNucleoside-TriphosphatasePeptide HydrolasesPeptidesProtease InhibitorsSerine EndopeptidasesViral Nonstructural ProteinsViral Proteases

Identifiers

PMID37140437
PMCPMC10501127
OpenAlexW4368355808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.