Evidence map›Paper›PMID 37140391›Full record

ArticleMicrobiology spectrum2023

Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens.

Sören M M Schuler, Gerrit Jürjens, Alexander Marker, Ulrike Hemmann, Astrid Rey, Stéphane Yvon, Marjorie Lagrevol, Mohamed Hamiti, Fabian Nguyen, Rolf Hirsch and 7 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The Evolution of ABC Importers.Journal of molecular biology · 2025
    Review
  3. Article
  4. Natural Products That Contain Higher Homologated Amino Acids.Chembiochem : a European journal of chemical biology · 2024
    Review
  5. Total Synthesis of GE81112A: An Orthoester-Based Approach.The Journal of organic chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sören M M SchulerBranch Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology, Giessen, Germany.ORCID 0000-0003-1089-8873
Gerrit JürjensBranch Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology, Giessen, Germany.
Alexander MarkerSanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
Ulrike HemmannSanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
Astrid ReySanofi R&D, Therapeutic Area Infectious Diseases, Marcy L'Etoile, France.
Stéphane YvonSanofi R&D, Therapeutic Area Infectious Diseases, Marcy L'Etoile, France.
Marjorie LagrevolSanofi R&D, Therapeutic Area Infectious Diseases, Marcy L'Etoile, France.
Mohamed HamitiSanofi R&D, Therapeutic Area Infectious Diseases, Marcy L'Etoile, France.
Fabian NguyenGene Center, Department for Biochemistry and Center for Protein Science Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
Rolf HirschBranch Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology, Giessen, Germany.
Christoph PöverleinSanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
Andreas VilcinskasBranch Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology, Giessen, Germany.ORCID 0000-0001-8276-4968
Peter HammannSanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
Daniel N WilsonGene Center, Department for Biochemistry and Center for Protein Science Munich, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0003-3816-3828
Michael MourezSanofi R&D, Therapeutic Area Infectious Diseases, Marcy L'Etoile, France.
Sebastien CoyneSanofi R&D, Therapeutic Area Infectious Diseases, Marcy L'Etoile, France.
Armin BauerSanofi-Aventis Deutschland GmbH, Frankfurt, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After the first total synthesis combined with structure revision, we performed thorough

Indexed as

Anti-Bacterial AgentsEscherichia coli InfectionsAnimalsDrug Resistance, Multiple, BacterialGram-Negative BacteriaHumansMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsantibioticGE81112Aprofiling

Identifiers

PMID37140391
PMCPMC10269895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.