Evidence map›Paper›PMID 37140388›Full record

ArticleAntimicrobial agents and chemotherapy2023

α-Mangostin Exhibits a Therapeutic Effect on Spinal Cystic Echinococcosis by Affecting Glutamine Metabolism.

Sibo Wang, Haohao Sun, Shan Wang, Qian Ren, Yi Dai, Meipeng Zhu, Yayun Zhang, Honglei Kang, Jing Li, Jun Xiao and 2 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sibo WangDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Haohao SunThe First Affiliated Hospital of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, China.
Shan WangThe First Affiliated Hospital of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, China.
Qian RenThe First Affiliated Hospital of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, China.
Yi DaiThe First Affiliated Hospital of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, China.
Meipeng ZhuDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yayun ZhangDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Honglei KangDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jing LiThe First Affiliated Hospital of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, China.
Jun XiaoThe First Affiliated Hospital of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, China.
Yimin DongDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Weishan WangThe First Affiliated Hospital of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, China.ORCID 0000-0002-7889-744X
Shihezi University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cystic echinococcosis, a severely neglected, rare disease, is characterized by high morbidity, disability, and mortality in prevalent regions. Due to the high-risk nature of surgical treatment and the ineffectiveness of conventional drugs, there is an unmet need for novel safe and effective drugs for the treatment of this disease. In this study, we examined the therapeutic effects of α-mangostin for spinal cystic echinococcosis, and explored its potential pharmacological mechanism. The repurposed drug exhibited a potent

Indexed as

EchinococcosisXanthonesGlutamineHumansProteinsGlutaminemangostinProteinsXanthonesanti-echinococcosisautophagyglutaminespinal echinococcosisα-mangostin

Identifiers

PMID37140388
PMCPMC10269084
OpenAlexW4368360972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.