Evidence map›Paper›PMID 37140376›Full record

ArticleMicrobiology spectrum2023

Ana C O Souza, Wenbo Ge, Nathan P Wiederhold, Jeffrey M Rybak, Jarrod R Fortwendel, P David Rogers

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Genotype-Phenotype Relationships in Azole-ResistantJournal of fungi (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  10. Molecular Identification ofInfection and drug resistance · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ana C O SouzaDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Wenbo GeDepartment of Clinical Pharmacy and Translational Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Nathan P WiederholdFungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Jeffrey M RybakDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jarrod R Fortwendel *Department of Clinical Pharmacy and Translational Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
P David Rogers *Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-4401-0679
St. Jude Children's Research Hospital · USUniversity of Tennessee Health Science Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

Non-cyp51A-mutation Mediated Triazole Resistance in Aspergillus fumigatusR01AI143197 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI FORTWENDEL, JARROD R., ROGERS, P. DAVID · 2020 to 2024
$3.3M
NIAID NIH HHS R01 AI143197
6 · The paper itself

Abstract

Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal drugs to treat A. fumigatus infections, but their use in the clinic is threatened by the emergence of triazole-resistant isolates worldwide, reinforcing the need for a better understanding of resistance mechanisms. The predominant mechanisms of A. fumigatus triazole resistance involve mutations affecting the promoter region or coding sequence of the target enzyme of the triazoles, Cyp51A. However, triazole-resistant isolates without

Indexed as

AspergillosisAspergillus fumigatusAntifungal AgentsDrug Resistance, FungalFungal ProteinsHumansMicrobial Sensitivity TestsTriazolesAntifungal AgentsFungal ProteinsTriazolesAspergillus fumigatusCCAAT box binding complexhapEhmg1triazole drug resistance

Identifiers

PMID37140376
PMCPMC10269825
OpenAlexW4368361355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.