Evidence map›Paper›PMID 37140215›Full record

ArticleHeadache2023

Validation of the Utah Photophobia Symptom Impact Scale (version 2) as a headache-specific photophobia assessment tool.

Melissa M Cortez, Cecilia Martindale, K C Brennan, Jacob Kean, Morgan M Millar, Alexander Knudson, Bradley J Katz, Kathleen B Digre, Angela P Presson, Chong Zhang

Abstract read
In one paragraph

Article in Headache, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Melissa M CortezDepartment of Neurology, University of Utah, Salt Lake City, USA.ORCID 0000-0001-5015-441X
Cecilia MartindaleDepartment of Neurology, University of Utah, Salt Lake City, USA.
K C BrennanDepartment of Neurology, University of Utah, Salt Lake City, USA.ORCID 0000-0003-4193-5841
Jacob KeanDepartment of Population Health Sciences, University of Utah, Salt Lake City, USA.
Morgan M MillarDepartment of Internal Medicine, University of Utah, Salt Lake City, USA.
Alexander KnudsonSchool of Medicine, University of Utah, Salt Lake City, USA.
Bradley J KatzDepartment of Neurology, University of Utah, Salt Lake City, USA.ORCID 0000-0002-8948-7120
Kathleen B DigreDepartment of Neurology, University of Utah, Salt Lake City, USA.
Angela P PressonDepartment of Internal Medicine, University of Utah, Salt Lake City, USA.
Chong ZhangDepartment of Internal Medicine, University of Utah, Salt Lake City, USA.

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Astrocytic mechanisms in a new genetic model of migraineR01NS104742 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2018 to 2022
$2.5M
Noncanonical glutamate signaling in the origins of the migraine attackR37NS102978 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Kevin Christopher Brennan · 2024 to 2026
$2.0M
Cortical Spreading Depression in the Origins of the Migraine AttackR01NS102978 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2017 to 2021
$1.7M
Photophobia and Pupillary Autonomic Dysfunction as Biomarkers of Post-Traumatic HeadacheK23NS105920 · NINDS · UNIVERSITY OF UTAH · PI CORTEZ, MELISSA · 2020 to 2024
$996k
Elucidating Brainstem Contributions to Visceral and Somatic Motor Dysfunction after mTBIR21HD100897 · NICHD · UNIVERSITY OF UTAH · PI FINO, PETER C · 2020 to 2021
$419k
Medical Student Research Program (MSRP) in Eye Health and DiseaseT35EY026511 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Alessandra Angelucci, Brian Stagg · 2016 to 2026
$251k
NCATS NIH HHS UL1 TR002538NEI NIH HHS T35 EY026511NHLBI NIH HHS T35EY026511NICHD NIH HHS R21 HD100897NINDS NIH HHS K23 NS105920NINDS NIH HHS R01 NS102978NINDS NIH HHS R01 NS104742NINDS NIH HHS R37 NS102978
6 · The paper itself

Abstract

objectiveTo present an updated version of the Utah Photophobia Symptom Impact Scale version 2 (UPSIS2), providing robust clinical and psychometric validation, to improve headache-specific evaluation of light sensitivity and headache-related photophobia.

backgroundThe original UPSIS filled a gap in available tools for assessment of headache-associated light sensitivity by providing patient-reported evaluation of the impact of light sensitivity on activities of daily living (ADLs). We have since revised the original questionnaire to provide a more robust item construct and refined validation approach.

methodsWe conducted a psychometric validation of the UPSIS2 through a primary analysis of an online survey of volunteers with recurrent headaches recruited from the University of Utah clinics and surrounding community. Volunteers completed the original UPSIS and UPSIS2 questionnaire versions in addition to measures of headache impact, disability, and frequency. The UPSIS2 now includes a pre-defined recall period and a 1-4 Likert scale with standardized response anchors to improve clarity. Internal construct validity, external construct validity, and test-retest reliability, were evaluated.

resultsResponses were obtained from 163 volunteers, with UPSIS2 scores ranging from 15 to 57 (out of a possible 15-60) with a mean (standard deviation) of 32.4 (8.80). Construct validity was satisfactory, as evidenced by sufficient unidimensionality, monotonicity, and local independence. Reliability was excellent, with Rasch test reliability = 0.90 and Cronbach's alpha = 0.92, and an intraclass correlation of 0.79 (95% confidence interval 0.65-0.88) for participants who took the test twice. UPSIS2 correlates well with other headache measures (Spearman's correlations >0.50), as well as the original UPSIS (Spearman's correlation = 0.87), indicating good convergent validity. UPSIS2 scores differ significantly across International Classification of Headache Disorders (third edition) groups, indicating good known group validity.

conclusionThe UPSIS2 provides a well-validated headache-specific outcome measure for the assessment of photophobia impact on ADLs.

Indexed as

Activities of Daily LivingPhotophobiaHeadacheHumansPsychometricsReproducibility of ResultsSurveys and QuestionnairesUtahheadache-related disabilitymigrainephotophobia

Identifiers

PMID37140215
PMCPMC10368178

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.