Evidence map›Paper›PMID 37140079›Full record

ReviewNatural product reports2023

Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers.

Zhi Xu, Xin Li, John A Rose, Seth B Herzon

Abstract readReview
In one paragraph

Review in Natural product reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhi XuDepartment of Chemistry, Yale University, New Haven, Connecticut, 06520, USA. seth.herzon@yale.edu.ORCID 0000-0002-1476-1367
Xin LiDepartment of Chemistry, Yale University, New Haven, Connecticut, 06520, USA. seth.herzon@yale.edu.ORCID 0000-0002-8840-0695
John A RoseDepartment of Chemistry, Yale University, New Haven, Connecticut, 06520, USA. seth.herzon@yale.edu.
Seth B HerzonDepartment of Chemistry, Yale University, New Haven, Connecticut, 06520, USA. seth.herzon@yale.edu.ORCID 0000-0001-5940-9853

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Synthetic and translational studies of antitumor and antimicrobial natural products.R35GM131913 · NIGMS · YALE UNIVERSITY · PI Seth B. Herzon · 2019 to 2026
$4.7M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS R35 GM131913
6 · The paper itself

Abstract

Covering: up to 2022Tricyclic bridgehead carbon centers (TBCCs) are a synthetically challenging substructure found in many complex natural products. Here we review the syntheses of ten representative families of TBCC-containing isolates, with the goal of outlining the strategies and tactics used to install these centers, including a discussion of the evolution of the successful synthetic design. We provide a summary of common strategies to inform future synthetic endeavors.

Indexed as

Biological ProductsCarbonBiological ProductsCarbon

Identifiers

PMID37140079
PMCPMC10472132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.