Evidence map›Paper›PMID 37140029›Full record

ArticleHeadache2023

Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space.

Xue Zhang, Wei Wang, Xueyan Zhang, Xiaoyan Bai, Ziyu Yuan, Peng Zhang, Ruiliang Bai, Bingjie Jiao, Yingkui Zhang, Zhiye Li and 5 more

Open access · bronzeAbstract readComment
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In one paragraph

Article in Headache, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  9. Article
  10. Reliability and Spatial Consistency of MR Diffusion Tensor Imaging Measures Along the Cerebral Perivascular Space.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Xue ZhangTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.ORCID 0000-0002-9877-9467
Wei WangHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-2302-6273
Xueyan ZhangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-9898-6423
Xiaoyan BaiTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Ziyu YuanHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peng ZhangHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ruiliang BaiDepartment of Physical Medicine and Rehabilitation of the Affiliated Sir Run Shumen Shaw Hospital and Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China.
Bingjie JiaoKey Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Yingkui ZhangTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Zhiye LiTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Hefei TangHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yaqing ZhangHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xueying YuHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yonggang WangHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Binbin SuiTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.ORCID 0000-0002-1052-6992
Capital Medical University · CNAllen Institute for Brain Science · USBeijing Tian Tan Hospital · CNNational Clinical Research Center for Digestive Diseases · CNZhejiang University · CN

Funding

Beijing Municipal Natural Science Foundation 7212028National Natural Science Foundation of Beijing Z200024National Natural Science Foundation of China 31770800National Natural Science Foundation of China 32170752National Natural Science Foundation of China 91849104
6 · The paper itself

Abstract

objectivesTo investigate the glymphatic function in patients with new daily persistent headache (NDPH) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method.

backgroundNDPH, a rare and treatment-refractory primary headache disorder, is poorly understood. There is limited evidence to suggest that headaches are associated with glymphatic dysfunction. Thus far, no studies have evaluated glymphatic function in patients with NDPH.

methodsIn this cross-sectional study conducted in the Headache Center of Beijing Tiantan Hospital, patients with NDPH and healthy controls were enrolled. All participants underwent brain magnetic resonance imaging examinations. Clinical characteristics and neuropsychological evaluation were examined in patients with NDPH. ALPS indexes for both hemispheres were measured to determine the glymphatic system function in patients with NDPH and healthy controls.

resultsIn total, 27 patients with NDPH (14 males, 13 females; age [mean ± standard deviation (SD)]: 36.6 ± 20.6) and 33 healthy controls (15 males, 18 females; age [mean ± SD]: 36.0 ± 10.8) were included in the analysis. No significant differences between groups were observed in the left ALPS index (1.583 ± 0.182 vs. 1.586 ± 0.175, mean difference = 0.003, 95% confidence interval [CI] of difference = -0.089 to 0.096, p = 0.942), or right ALPS index (1.578 ± 0.230 vs. 1.559 ± 0.206, mean difference = -0.027, 95% CI of difference = -0.132 to 0.094, p = 0.738). Additionally, ALPS indexes were not correlated with clinical characteristics or neuropsychiatric scores.

conclusionNo glymphatic dysfunction was detected in patients with NDPH by means of the ALPS method. Additional studies with larger samples are needed to confirm these preliminary findings and improve the understanding of glymphatic function in NDPH.

Indexed as

Glymphatic SystemHeadache DisordersCross-Sectional StudiesFemaleHeadacheHumansMaleNeurologic Examinationdiffusion tensor imagingglymphatic systemmagnetic resonance imagingnew daily persistent headache

Identifiers

PMID37140029
OpenAlexW4368361095

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.