Evidence map›Paper›PMID 37139980›Full record

ReviewJournal of the National Cancer Institute. Monographs2023

Metabolic and bariatric surgery and obesity pharmacotherapy for cancer prevention: current status and future possibilities.

Mary C Playdon, Sheetal Hardikar, Prasoona Karra, Rachel Hoobler, Anna R Ibele, Katherine L Cook, Amanika Kumar, Joseph E Ippolito, Justin C Brown

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of the National Cancer Institute. Monographs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Mary C PlaydonDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Sheetal HardikarCancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, UT, USA.
Prasoona KarraDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Rachel HooblerDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Anna R IbeleDepartment of Surgery, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Katherine L CookDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-6241-0214
Amanika KumarDivision of Gynecologic Surgery, Mayo Clinic, Rochester, MN, USA.
Joseph E IppolitoMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1913-5573
Justin C BrownPennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID 0000-0001-7540-4913
University of Utah · USMallinckrodt (United States) · USMayo Clinic in Arizona · USPennington Biomedical Research Center · USWake Forest University · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sylvia Goldman · 2012 to 2026
$69.1M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Robert Lee Newton · 2005 to 2026
$26.5M
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon CancerU01CA271279 · NCI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Justin C Brown, JEFFREY A MEYERHARDT · 2022 to 2026
$4.9M
Ceramides as novel drivers of metabolic dysfunction and colorectal cancerU01CA272529 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Mary Christine Playdon, SCOTT A SUMMERS · 2022 to 2026
$4.7M
Transdisciplinary Research in Energetics and Cancer (TREC) Training GrantR25CA203650 · NCI · YALE UNIVERSITY · PI IRWIN, MELINDA L · 2016 to 2025
$2.9M
Diabetes, Medications and the Cost-Effectiveness of Screening for Colorectal NeoplasiaK07CA222060 · NCI · UNIVERSITY OF UTAH · PI HARDIKAR, SHEETAL · 2018 to 2022
$791k
NCI NIH HHS K07 CA222060NCI NIH HHS P50 CA136393NCI NIH HHS U01 CA271279NCI NIH HHS U01 CA272529NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940NIH HHS P30 DK072476NIH HHS R25 CA203650NIH HHS U54 GM104940
6 · The paper itself

Abstract

Obesity is a chronic, relapsing, progressive disease of excess adiposity that increases the risk of developing at least 13 types of cancer. This report provides a concise review of the current state of the science regarding metabolic and bariatric surgery and obesity pharmacotherapy related to cancer risk. Meta-analyses of cohort studies report that metabolic and bariatric surgery is independently associated with a lower risk of incident cancer than nonsurgical obesity care. Less is known regarding the cancer-preventive effects of obesity pharmacotherapy. The recent approval and promising pipeline of obesity drugs will provide the opportunity to understand the potential for obesity therapy to emerge as an evidence-based cancer prevention strategy. There are myriad research opportunities to advance our understanding of how metabolic and bariatric surgery and obesity pharmacotherapy may be used for cancer prevention.

Indexed as

Bariatric SurgeryNeoplasmsAdiposityHumansObesityRisk

Identifiers

PMID37139980
PMCPMC10157771
OpenAlexW4368339839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.