Evidence map›Paper›PMID 37139662›Full record

ArticleCell proliferation2023

Preventing acute liver injury via hepatocyte-targeting nano-antioxidants.

Xuejiao Yuan, Yanfeng Zhou, Jinli Sun, Shanshan Wang, Xingjie Hu, Jiyu Li, Jing Huang, Nan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
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  10. Nanotherapeutics for Alleviating Anesthesia-Associated Complications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xuejiao YuanCollege of Chemistry and Materials Science, The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai, China.
Yanfeng ZhouSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-5103-2879
Jinli SunSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanshan WangCollege of Chemistry and Materials Science, The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai, China.
Xingjie HuSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiyu LiSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing HuangDepartment of Neurology, Xuhui District Central Hospital, Shanghai, China.
Nan ChenCollege of Chemistry and Materials Science, The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai, China.ORCID https://orcid.org/0000-0001-8536-6631
Shanghai Jiao Tong University · CNShanghai Normal University · CNShanghai Xuhui Central Hospital · CN

Funding

Major Science and Technology Innovation Program of Shanghai Municipal Education Commission 2019-01-07-00-01-E00059National Key R&D Program of China 2021YFF0701800National Natural Science Foundation of China 21974089Natural Science Foundation of Shanghai 21ZR1436600Shanghai Sailing Program 20YF1422200
6 · The paper itself

Abstract

Acute liver injury (ALI) is a severe liver disease that is characterized by sudden and massive hepatocyte necrosis and deterioration of liver functions. Oxidative stress is increasingly recognized as a key factor in the induction and progression of ALI. Scavenging excessive reactive oxygen species (ROS) with antioxidants has become a promising therapeutic option, but intrinsically hepatocyte-targeting antioxidants with excellent bioavailability and biocompatibility are yet to be developed. Herein, self-assembling nanoparticles (NPs) composed of amphiphilic polymers are introduced to encapsulate organic Selenium compound L-Se-methylselenocysteine (SeMC) and form SeMC NPs, which protect the viabilities and functions of cultured hepatocytes in drug- or chemical-induced acute hepatotoxicity models via efficient ROS removal. After further functionalization with the hepatocyte-targeting ligand glycyrrhetinic acid (GA), the resultant GA-SeMC NPs exhibit enhanced hepatocyte uptake and liver accumulation. In mouse models of ALI induced by acetaminophen (APAP) or carbon tetrachloride (CCl

Indexed as

AntioxidantsGlycyrrhetinic AcidAnimalsHepatocytesLiverMiceMice, Inbred C57BLOxidative StressReactive Oxygen SpeciesAntioxidantsGlycyrrhetinic AcidReactive Oxygen Species

Identifiers

PMID37139662
PMCPMC10693184
OpenAlexW4368361969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.