ArticleJournal of veterinary internal medicine
Immune-mediated polyneuropathy in cats: Clinical description, electrodiagnostic assessment, and treatment.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Feline neurological disease in a veterinary referral hospital in the UK: clinical diagnosis, neuroanatomical localisation and VITAMIN D-based aetiological distribution.Journal of feline medicine and surgery · 2026Article
- Cervical ventroflexion in cats: 86 cases (2003-2024).Journal of feline medicine and surgery · 2025Article
- Presumptive motor neuron degeneration in an adult cat.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- Immune-mediated polyneuropathy in cats: Clinical description, electrodiagnostic assessment, and treatment.Journal of veterinary internal medicineArticle
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuspected immune-mediated polyneuropathy has been increasingly reported in cats, especially in the last decade, but the condition remains poorly understood.
objectivesRefine the clinical description and review the classification of this condition based on electrodiagnostic investigation and evaluate the benefit of corticosteroid treatment and L-carnitine supplementation. ANIMALS: Fifty-five cats presented with signs of muscular weakness and electrodiagnostic findings consistent with polyneuropathy of unknown origin.
methodsRetrospective, multicenter study. Data from the medical records were reviewed. The owners were contacted by phone for follow-up at the time of the study.
resultsThe male-to-female ratio was 2.2. The median age of onset was 10 months, with 91% of affected cats being <3 years of age. Fourteen breeds were represented in the study. The electrodiagnostic findings supported purely motor axonal polyneuropathy. Histological findings from nerve biopsies were consistent with immune-mediated neuropathy in 87% of the tested cats. The overall prognosis for recovery was good to excellent, as all but 1 cat achieved clinical recovery, with 12% having mild sequelae and 28% having multiple episodes during their lifetime. The outcome was similar in cats with no treatment when compared with cats receiving corticosteroids or L-carnitine supplementation. CONCLUSIONS AND CLINICAL IMPORTANCE: Immune-mediated motor axonal polyneuropathy should be considered in young cats with muscle weakness. This condition may be similar to acute motor axonal neuropathy in Guillain-Barré syndrome patients. Based on our results, diagnostic criteria have been proposed.
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