Evidence map›Paper›PMID 37139528›Full record

ReviewFrontiers in neuroscience2023

Whole-brain imaging of freely-moving zebrafish.

Hamid Hasani, Jipeng Sun, Shuyu I Zhu, Qiangzhou Rong, Florian Willomitzer, Rumelo Amor, Gail McConnell, Oliver Cossairt, Geoffrey J Goodhill

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  9. Review
  10. Purkinje Cell Spatial Correlation Dynamics Are Key to Cerebellar Cortical Contributions to Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Review
  12. Article
  13. A perspective on neuroethology: what the past teaches us about the future of neuroethology.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024
    Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Hamid Hasani *Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, United States.
Jipeng Sun *Department of Computer Science, Northwestern University, Evanston, IL, United States.
Shuyu I Zhu *Departments of Developmental Biology and Neuroscience, Washington University in St. Louis, St. Louis, MO, United States.
Qiangzhou RongDepartments of Developmental Biology and Neuroscience, Washington University in St. Louis, St. Louis, MO, United States.
Florian WillomitzerWyant College of Optical Sciences, University of Arizona, Tucson, AZ, United States.
Rumelo AmorQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Gail McConnellCentre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Oliver CossairtDepartment of Computer Science, Northwestern University, Evanston, IL, United States.
Geoffrey J GoodhillDepartments of Developmental Biology and Neuroscience, Washington University in St. Louis, St. Louis, MO, United States.
Northwestern University · USWashington University in St. Louis · USThe University of Queensland · AUUniversity of Arizona · USUniversity of Strathclyde · GB

Funding

Revealing neural circuits underlying zebrafish behavior using mesoscopic light field microscopyR34NS123913 · NINDS · WASHINGTON UNIVERSITY · PI COSSAIRT, OLIVER STRIDES, GOODHILL, GEOFFREY J · 2021 to 2021
$674k
NINDS NIH HHS R34 NS123913
6 · The paper itself

Abstract

One of the holy grails of neuroscience is to record the activity of every neuron in the brain while an animal moves freely and performs complex behavioral tasks. While important steps forward have been taken recently in large-scale neural recording in rodent models, single neuron resolution across the entire mammalian brain remains elusive. In contrast the larval zebrafish offers great promise in this regard. Zebrafish are a vertebrate model with substantial homology to the mammalian brain, but their transparency allows whole-brain recordings of genetically-encoded fluorescent indicators at single-neuron resolution using optical microscopy techniques. Furthermore zebrafish begin to show a complex repertoire of natural behavior from an early age, including hunting small, fast-moving prey using visual cues. Until recently work to address the neural bases of these behaviors mostly relied on assays where the fish was immobilized under the microscope objective, and stimuli such as prey were presented virtually. However significant progress has recently been made in developing brain imaging techniques for zebrafish which are not immobilized. Here we discuss recent advances, focusing particularly on techniques based on light-field microscopy. We also draw attention to several important outstanding issues which remain to be addressed to increase the ecological validity of the results obtained.

Indexed as

behaviorcalcium imagingimage deconvolutionlight-field microscopyzebrafish

Identifiers

PMID37139528
PMCPMC10150962
OpenAlexW4366206434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.