Evidence map›Paper›PMID 37139426›Full record

ArticleActa pharmaceutica Sinica. B2023

Ultrasmall, elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers.

Lu Su, Kellie S Dalby, Hannah Luehmann, Sussana A Elkassih, Sangho Cho, Xun He, Lisa Detering, Yen-Nan Lin, Nari Kang, Dennis A Moore and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Discovery and evaluation of a novelActa pharmaceutica Sinica. B · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Lu SuDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Kellie S DalbyDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Hannah LuehmannMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Sussana A ElkassihDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Sangho ChoDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Xun HeDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Lisa DeteringMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Yen-Nan LinDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Nari KangDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Dennis A MooreBayer AG, Creve Coeur, MO 63167, USA.
Richard LaforestMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Guorong SunDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Karen L WooleyDepartment of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Texas A&M University · USMallinckrodt (United States) · USBayer (United States) · USEindhoven University of Technology · NL

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Acquisition of high-resolution PET/CT preclinical imaging instrument at MIRS10OD030403 · OD · WASHINGTON UNIVERSITY · PI SHOGHI, KOORESH ISAAC · 2021 to 2021
$929k
NCI NIH HHS P30 CA091842NIH HHS S10 OD030403
6 · The paper itself

Abstract

To expand the single-dose duration over which noninvasive clinical and preclinical cancer imaging can be conducted with high sensitivity, and well-defined spatial and temporal resolutions, a facile strategy to prepare ultrasmall nanoparticulate X-ray contrast media (nano-XRCM) as dual-modality imaging agents for positron emission tomography (PET) and computed tomography (CT) has been established. Synthesized from controlled copolymerization of triiodobenzoyl ethyl acrylate and oligo(ethylene oxide) acrylate monomers, the amphiphilic statistical iodocopolymers (ICPs) could directly dissolve in water to afford thermodynamically stable solutions with high aqueous iodine concentrations (>140 mg iodine/mL water) and comparable viscosities to conventional small molecule XRCM. The formation of ultrasmall iodinated nanoparticles with hydrodynamic diameters of

Indexed as

Amphiphilic statistical iodocopolymerCTLongitudinal tumor monitoringPET/CTUltrasmall nanoassemblyX-ray contrast media

Identifiers

PMID37139426
PMCPMC10149980
OpenAlexW4296050492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.