ArticleFrontiers in aging neuroscience2023
(A)symmetry during gait initiation in people with Parkinson's disease: A motor and cortical activity exploratory study.
Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Anticipatory postural adjustments during gait initiation in people with parkinson's disease: a systematic review.Acta neurologica Belgica · 2026Pooled it
- Gait asymmetry in Parkinson's disease - a systematic review and meta-analysis (AsymmGait-Parkinson study).Scientific reports · 2026Pooled it
- Cognitive load alters cortical dynamics during gait in Parkinson's disease but not in neurologically healthy individuals.Cognitive neurodynamics · 2026Article
- Accuracy and Inter-Subject Variability of Gait Event Detection Methods Based on Optical and Inertial Motion Capture.Sensors (Basel, Switzerland) · 2025Article
- L-Dopa Comparably Improves Gait and Limb Movements in Parkinson's Disease: A Wearable Sensor Analysis.Biomedicines · 2025Article
- Rhythmic auditory cues improve gait asymmetry during unobstructed walking in people with Parkinson's disease but have no effect on obstacle avoidance - AsymmGait-Parkinson study.Frontiers in aging neuroscience · 2025Article
- Differentiation in theta and gamma activation in weight-shifting learning between people with parkinson's disease of different anxiety severities.GeroScience · 2024Article
- Transient Increases in Neural Oscillations and Motor Deficits in a Mouse Model of Parkinson's Disease.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson's disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle. Objective: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD. Methods: Sixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases. Results: Parkinson's disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior-posterior displacement ( Conclusion: Parkinson's disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD.
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