Evidence map›Paper›PMID 37139062›Full record

ArticleFrontiers in neurology2023

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy.

Fengjun Zhu, Hanwen Wang, Lin Li, Anatol Bragin, Dezhi Cao, Yuan Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Fengjun ZhuDepartment of Neurosurgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Hanwen WangDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, United States.
Lin LiDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, United States.
Anatol BraginDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, United States.
Dezhi CaoDepartment of Neurosurgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Yuan ChengDepartment of Neurosurgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
University of California, Los Angeles · USChongqing Medical University · CNDalian Medical University · CNShenzhen Children's Hospital · CN

Funding

New approach for identification pHFO networks to predict epileptogenesisR16NS131108 · NINDS · UNIVERSITY OF NORTH TEXAS · PI Lin Li · 2022 to 2026
$1.3M
NINDS NIH HHS R16 NS131108
6 · The paper itself

Abstract

Objective: To test the feasibility and reliability of intracranial electrophysiological recordings in an acute status epilepticus model on laboratory swine. Method: Intrahippocampal injection of kainic acid (KA) was performed on 17 male Bama pigs ( Results: The KA dosage test suggested that a 10 μl (1.0 μg/μl) intrahippocampal injection could successfully evoke status epilepticus lasting from 4 to 12 h. At this dosage, eight pigs (50% of total) had prolonged epileptic events (tonic-chronic seizures + interictal spikes Significance: This study measured intracranial electrophysiological activity in a swine model of KA-induced mesial temporal lobe epilepsy (mTLE). Using the clinical SEEG electrode, we distinguished abnormal EEG patterns in the swine brain. The high test-retest reliability of HFO rates in the post-KA period suggests the utility of this model for studying mechanisms of epileptogenesis. The use of swine may provide satisfactory translational value for clinical epilepsy research.

Indexed as

high-frequency oscillationskainic acidmesial temporal lobe epilepsystatus epilepticusswine model

Identifiers

PMID37139062
PMCPMC10150775
OpenAlexW4366168580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.