ArticleAdvanced functional materials2018
Rapid Soft Tissue Approximation and Repair using Laser-activated Silk Nanosealants.
Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Skin repair and infection control in diabetic, obese mice using bioactive laser-activated sealants.Biomaterials · 2024Article
- In situ light-activated materials for skin wound healing and repair: A narrative review.Bioengineering & translational medicine · 2024Review
- Bioactive nanomaterials kickstart early repair processes and potentiate temporally modulated healing of healthy and diabetic wounds.Biomaterials · 2024Article
- Inflammasome modulation with P2X7 inhibitor A438079-loaded dressings for diabetic wound healing.Frontiers in immunology · 2024Article
- Laser tissue soldering of the gastrointestinal tract: A systematic review LTS of the gastrointestinal tract.Heliyon · 2023Review
- Temporal evaluation of efficacy and quality of tissue repair upon laser-activated sealing.Bioengineering & translational medicine · 2023Article
- Methods for Silk Property Analyses across Structural Hierarchies and Scales.Molecules (Basel, Switzerland) · 2023Review
- Ice-templated synthesis of multicomponent porous coatings via vapour sublimation and deposition polymerization.Materials today. Bio · 2022Article
- Bio-macromolecular design roadmap towards tough bioadhesives.Chemical Society reviews · 2022Review
- Antimicrobial laser-activated sealants for combating surgical site infections.Biomaterials science · 2021Article
- Carbon Nanotubes/Regenerated Silk Composite as a Three-Dimensional Printable Bio-Adhesive Ink with Self-Powering Properties.ACS applied materials & interfaces · 2021Article
- Copper-Eluting Fibers for Enhanced Tissue Sealing and Repair.ACS applied materials & interfaces · 2020Article
- Enzymatic Degradation ofBiomacromolecules · 2020Review
- Plasticised Regenerated Silk/Gold Nanorods Hybrids as Sealant and Bio-Piezoelectric Materials.Nanomaterials (Basel, Switzerland) · 2020Article
- Light-Activated Tissue-Integrating Sutures as Surgical Nanodevices.Advanced healthcare materials · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Tissue approximation and repair have been conventionally performed with sutures and staples, but these means are inherently traumatic. Tissue approximation using laser-responsive nanomaterials can lead to rapid tissue sealing and repair, and is an attractive alternative to existing clinical methods. Here, we demonstrate the use of laser-activated nanosealants (LANS) with gold nanorods (GNRs) embedded in silk fibroin polypeptide matrices. The adaptability of LANS for sealing soft tissues is demonstrated using two different modalities: insoluble thin films for internal, intestinal tissue repair, and semi-soluble pastes for external repair, shown by skin repair in live mice. Laser repaired intestinal tissue held over seven times more fluid pressure than sutured intestine and also prevented bacterial leakage. Skin incisions in mice closed using LANS' showed indication of increased mechanical strength and faster repair compared to suturing. Laser-activated silk-GNR nanosealants rapidly seal soft-tissue tears and show high promise for tissue approximation and repair in trauma and routine surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.