Observational studyFrontiers in immunology2023
The oral microbiome of patients with ischemic stroke predicts their severity and prognosis.
Observational study in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Diversity and taxonomic differences in the oral microbiota of stroke patients: a systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Effects of electroacupuncture on neurological outcomes and brain-gut axis-associated changes in experimental ischemic stroke models: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Oral microbiota dysbiosis related to the cortical thinning and cognitive impairment in cerebral small vessel disease.Journal of oral microbiology · 2026Article
- Investigating the Relationships Among Gut Microbiota, Inflammatory Cytokines, Cerebrovascular Diseases, and the Mediation Pathways.Mediators of inflammation · 2026Article
- OralJournal of oral microbiology · 2026Article
- Reframing glucolipid metabolic disorders through the lens of the oral microbiome: from pathophysiological mechanisms to translational potential.Frontiers in nutrition · 2026Review
- Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults.Journal of the American Heart Association · 2025Observational
- Rhubarb with Different Cooking Methods Restored the Gut Microbiota Dysbiosis and SCFAs in Ischemic Stroke Mice.Molecular neurobiology · 2025Article
- Article
- Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale.Scientific reports · 2025Article
- Oral microbiota and central nervous system diseases: A review.Neuroprotection (Chichester, England) · 2025Review
- Distinct blood and oral microbiome profiles reveal altered microbial composition and functional pathways in myocardial infarction patients.Frontiers in cellular and infection microbiology · 2025Article
- Oral microbiome dysbiosis in acute ischemic stroke and transient ischemic attack patients.PloS one · 2025Article
- The tongue coating microbiome is perturbed in atrial fibrillation and partly normalized after catheter ablation.Frontiers in microbiology · 2025Article
- Distinctive salivary oral microbiome in patients with burning mouth syndrome depending on pain intensity compared to healthy subjects.Journal of dental sciences · 2025Article
- The Oral-Gut-Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke.CNS neuroscience & therapeutics · 2024Review
- Article
- Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review.Microorganisms · 2024Review
- The Human Microbiome-A Physiologic Perspective.Comprehensive Physiology · 2024Review
- Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury.Applied microbiology and biotechnology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objectives: Stroke is a common group of cerebrovascular diseases that can lead to brain damage or death. Several studies have shown a close link between oral health and stroke. However, the oral microbiome profiling of ischemic stroke (IS) and its potential clinical implication are unclear. This study aimed to describe the oral microbiota composition of IS, the high risk of IS, and healthy individuals and to profile the relationship between microbiota and IS prognosis. Methods: This observational study recruited three groups: IS, high-risk IS (HRIS), and healthy control (HC) individuals. Clinical data and saliva were collected from participants. The modified Rankin scale score after 90 days was used to assess the prognosis of stroke. Extracted DNA from saliva and performed 16S ribosomal ribonucleic acid (rRNA) gene amplicon sequencing. Sequence data were analyzed using QIIME2 and R packages to evaluate the association between the oral microbiome and stroke. Results: A total of 146 subjects were enrolled in this study according to the inclusion criteria. Compared with HC, HRIS and IS demonstrated a progressive increase trend in Chao1, observed species richness, and Shannon and Simpson diversity index. On the basis of permutational multivariate analysis of variance, the data indicate a great variation in the saliva microbiota composition between HC and HRIS (F = 2.40, P < 0.001), HC and IS (F = 5.07, P < 0.001), and HRIS and IS (F = 2.79, P < 0.001). The relative abundance of Discussion: In summary, the oral salivary microbiome of HRIS and IS subjects have a higher diversity, and the differential bacteria have some predictive value for the severity and prognosis of IS. Oral microbiota may be used as potential biomarkers in patients with IS.
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