Evidence map›Paper›PMID 37138859›Full record

ReviewFrontiers in immunology2023

MicroRNA: role in macrophage polarization and the pathogenesis of the liver fibrosis.

Wen Yu, Shu Wang, Yangyang Wang, Hui Chen, Hao Nie, Lian Liu, Xiaoting Zou, Quan Gong, Bing Zheng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  9. Review
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  12. miRNA in the Progression of Diabetic Kidney Disease: New Insight.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wen YuDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Shu WangDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Yangyang WangDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Hui ChenDepartment of Laboratory Medicine, First Affiliated Hospital of Yangtze University, Jingzhou, China.
Hao NieDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Lian LiuClinical Molecular Immunology Center, School of Medicine, Yangtze University, Jingzhou, China.
Xiaoting ZouDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Quan GongDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Bing ZhengDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Yangtze University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages, as central components of innate immunity, feature significant heterogeneity. Numerus studies have revealed the pivotal roles of macrophages in the pathogenesis of liver fibrosis induced by various factors. Hepatic macrophages function to trigger inflammation in response to injury. They induce liver fibrosis by activating hepatic stellate cells (HSCs), and then inflammation and fibrosis are alleviated by the degradation of the extracellular matrix and release of anti-inflammatory cytokines. MicroRNAs (miRNAs), a class of small non-coding endogenous RNA molecules that regulate gene expression through translation repression or mRNA degradation, have distinct roles in modulating macrophage activation, polarization, tissue infiltration, and inflammation regression. Considering the complex etiology and pathogenesis of liver diseases, the role and mechanism of miRNAs and macrophages in liver fibrosis need to be further clarified. We first summarized the origin, phenotypes and functions of hepatic macrophages, then clarified the role of miRNAs in the polarization of macrophages. Finally, we comprehensively discussed the role of miRNAs and macrophages in the pathogenesis of liver fibrotic disease. Understanding the mechanism of hepatic macrophage heterogeneity in various types of liver fibrosis and the role of miRNAs on macrophage polarization provides a useful reference for further research on miRNA-mediated macrophage polarization in liver fibrosis, and also contributes to the development of new therapies targeting miRNA and macrophage subsets for liver fibrosis.

Indexed as

Liver DiseasesMicroRNAsHumansInflammationLiver CirrhosisMacrophage ActivationMacrophagesMicroRNAsHSCliver fibrosisM1 macrophageM2 macrophagemacrophage polarizationmicroRNA

Identifiers

PMID37138859
PMCPMC10149999
OpenAlexW4366226498

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.