Evidence map›Paper›PMID 37138613›Full record

ArticleFrontiers in microbiology2023

Human milk-associated bacterial communities associate with the infant gut microbiome over the first year of life.

Sara N Lundgren, Juliette C Madan, Margaret R Karagas, Hilary G Morrison, Brock C Christensen, Anne G Hoen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sara N LundgrenDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Juliette C MadanDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Hilary G MorrisonJosephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, United States.
Brock C ChristensenDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Anne G HoenDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Dartmouth College · USChildren's Hospital at Dartmouth Hitchcock · USMarine Biological Laboratory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Microbial communities inhabiting the human infant gut are important for immune system development and lifelong health. One critical exposure affecting the bacterial colonization of the infant gut is consumption of human milk, which contains diverse microbial communities and prebiotics. We hypothesized that human milk-associated microbial profiles are associated with those of the infant gut. Methods: Maternal-infant dyads enrolled in the New Hampshire Birth Cohort Study ( Results: Clustering analysis identified three breast milk microbiome types (BMTs), characterized by differences in Discussion: We identified clusters of human milk and infant stool microbial communities that were associated in maternal-infant dyads at 6 weeks of life and found that milk microbial communities were more strongly associated with infant gut microbial communities in infants delivered operatively and after a lag period. These results suggest that milk microbial communities have a long-term effect on the infant gut microbiome both through sharing of microbes and other molecular mechanisms.

Indexed as

breastfeedingbreast milk microbiomecesarean deliveryinfant gut microbiomemicrobial co-occurrence

Identifiers

PMID37138613
PMCPMC10149717
OpenAlexW4366208084

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.