ArticleFrontiers in pediatrics2023
Association of n-3 polyunsaturated fatty acid intakes with juvenile myopia: A cross-sectional study based on the NHANES database.
Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The association between macronutrients intake and myopia risk: a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Identifying potential therapeutic targets for high myopia via a case-control study and Mendelian randomisation analyses of the human blood metabolome.Eye (London, England) · 2026Article
- The Role of Vitamin D and Selected Nutrients in the Development of Myopia in Children and Young Adults: A Narrative Review.Journal of clinical medicine · 2026Review
- Association Between Omega-3 Polyunsaturated Fatty Acids and Myopia: Results From the Two-Sample and Multi-Tissue Genomic Mendelian Randomization Study and KNHANES.Food science & nutrition · 2025Article
- Association of nutritional intake with myopia and astigmatism.Scientific reports · 2025Article
- Causal relationship between multiple types of food intake and myopia: a Mendelian randomization study.International journal of ophthalmology · 2025Article
- Associations of obesity defined comprehensively by body mass index and body fat percentage with osteopenia.Clinics (Sao Paulo, Brazil) · 2025Article
- Critical role of lipid metabolism in axial myopia development.International journal of ophthalmology · 2025Review
- The impact of bilberry extract combined with docosahexaenoic acid on the expression of Chrnb4 gene in the sclera of myopic guinea pigs.Frontiers in medicine · 2025Article
- Clinical advantages of multifocal soft contact lenses in myopia control for adolescents.American journal of translational research · 2025Article
- Omega-3 Polyunsaturated Fatty Acids as a Protective Factor for Myopia.American journal of ophthalmology · 2024Article
- Association between dietary inflammatory index and adolescent myopia based on the National Health and Nutrition Examination Survey.Scientific reports · 2024Article
- Interdependence of Nutrition, Physical Activity, and Myopia.Nutrients · 2024Review
- Association between ultra-processed food and osteoporosis: a cross-sectional study based on the NHANES database.Nutrition & metabolism · 2024Article
- Protective effects of docosahexaenoic acid combined with bilberry extract on myopic Guinea pigs.Frontiers in medicine · 2024Article
- Association of dietary inflammatory index and refractive status in American adolescents: NHANES 1999-2008.Frontiers in medicine · 2024Article
- The association between anthocyanin intake and myopia in adolescents: a cross-sectional study of NHANES.Frontiers in pediatrics · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Inflammation is involved in the development of myopia. n-3 polyunsaturated fatty acids (n-3 PUFAs) have vasodilating and anti-inflammatory effects, which may be involved in controlling myopia. It is of great significance to explore the relationship between n-3 PUFA intakes and juvenile myopia in order to control and alleviate myopia among teenagers through dietary intervention. Methods: Sociodemographic data, information of nutrient intakes, cotinine, PUFAs, and eye refractive status of 1,128 juveniles were extracted from the National Health and Nutrition Examination Survey (NHANES) database in this cross-sectional study. PUFAs contained total polyunsaturated fatty acid (TPFAs), alpha-linolenic acid, octadecatetraenoic acid, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Covariates were screened by comparison among groups of normal vision, low myopia, and high myopia. The association between n-3 PUFA intakes and the risk of juvenile myopia was evaluated using univariate and multivariate logistic regression analyses with odds ratios (ORs) and 95% confidence intervals (CIs). Results: Among the juveniles, 788 (70.68%) had normal vision, 299 (25.80%) had low myopia, and 41 (3.52%) had high myopia. There were significant differences in average EPA and DHA intakes among the three groups, and mean DPA and DHA intakes in the normal vision group were lower than those in the low myopia group ( Conclusion: A high dietary intake of EPA may be associated with a decreased risk of high myopia among juveniles. A further prospective study is needed to validate this observation.
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