Evidence map›Paper›PMID 37138243›Full record

ArticleBMC cancer2023

Laparoscopic versus open surgery for perihilar cholangiocarcinoma: a multicenter propensity score analysis of short- term outcomes.

Min Wang, Tingting Qin, Hang Zhang, Jingdong Li, Xiaxing Deng, Yuhua Zhang, Wenxing Zhao, Ying Fan, Dewei Li, Xuemin Chen and 15 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05402618 (Minimally Invasive Versus Open Surgery for Perihilar Cholangiocarcinoma), which is not on this map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05402618 completednot on this map

Minimally Invasive Versus Open Surgery for Perihilar Cholangiocarcinoma(PHC)：A Multicenter Real-world Study

TypeobservationalSponsorRenyi QinRan2018 to 2022Enrolled783ConditionsPerihilar CholangiocarcinomaArmsNo intervention
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 16 institutions in 1 country.

Min Wang *Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Tingting Qin *Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Hang Zhang *Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Jingdong Li *Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute of North Sichuan Medical College, Nanchong, 637000, China.
Xiaxing Deng *Department of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 310000, China.
Yuhua Zhang *Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310003, China.
Wenxing Zhao *Department of General Surgery, the Affiliated Hospital of Xuzhou Medical University Xuzhou, Jiangsu, 221000, China.
Ying Fan *Department of the Second General Surgery, Sheng Jing Hospital of China Medical University, Liaoning, 110000, China.
Dewei Li *Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xuemin Chen *Department of Hepatopancreatobiliary Surgery, Third Affiliated Hospital of Soochow University, Suzhou, 213003, China.
Yechen Feng *Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Siwei ZhuDepartment of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan, China.
Zhongqiang XingDepartment of Hepato-Pancreato-Biliary Surgery, the Second Hospital of Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Guangsheng YuShandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, 250022, China.
Jian XuDepartment of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute of North Sichuan Medical College, Nanchong, 637000, China.
Junjie XieDepartment of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 310000, China.
Changwei DouDepartment of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310003, China.
Hongqin MaDepartment of General Surgery, the Affiliated Hospital of Xuzhou Medical University Xuzhou, Jiangsu, 221000, China.
Gangshan LiuDepartment of the Second General Surgery, Sheng Jing Hospital of China Medical University, Liaoning, 110000, China.
Yue ShaoDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Weibo ChenDepartment of Hepatopancreatobiliary Surgery, Third Affiliated Hospital of Soochow University, Suzhou, 213003, China.
Jun LiuShandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, 250022, China. dr_liujun1967@126.com.
Jianhua LiuDepartment of Hepato-Pancreato-Biliary Surgery, the Second Hospital of Hebei Medical University, Shijiazhuang, 050017, Hebei, China. ljh@medmail.com.cn.
Xinmin YinDepartment of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan, China. 13319587618@163.com.
Renyi QinDepartment of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. ryqin@tjh.tjmu.edu.cn.
Tongji Hospital · CNAffiliated Hospital of North Sichuan Medical College · CNHunan Normal University · CNSoochow University · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNXuzhou Medical College · CNZhejiang Provincial People's Hospital · CNChina Medical University · CNHebei Medical University · CNHuazhong University of Science and Technology · CNRuijin Hospital · CNSecond Hospital of Hebei Medical University · CNShandong First Medical University · CNShandong Provincial Institute of Dermatology and Venereology · CNShanghai Jiao Tong University · CNSheng Jing Hospital · CN

Funding

National Key Research and Development Program of China 2019YFC1315905National Natural Science Foundation of China 81772950 to RY Q, 81773160 to MW, 81702792 to SM XNatural Science Foundation of Hubei Province 2017CFB467 to MWTongji Hospital Clinical Research Flagship Program 2019CR203 to RY QTongji Hospital Science Fund for Distinguished Young Scholars 2017 to MW
6 · The paper itself

Abstract

backgroundLaparoscopic surgery (LS) has been increasingly applied in perihilar cholangiocarcinoma (pCCA). In this study, we intend to compare the short-term outcomes of LS versus open operation (OP) for pCCA in a multicentric practice in China.

methodsThis real-world analysis included 645 pCCA patients receiving LS and OP at 11 participating centers in China between January 2013 and January 2019. A comparative analysis was performed before and after propensity score matching (PSM) in LS and OP groups, and within Bismuth subgroups. Univariate and multivariate models were performed to identify significant prognostic factors of adverse surgical outcomes and postoperative length of stay (LOS).

resultsAmong 645 pCCAs, 256 received LS and 389 received OP. Reduced hepaticojejunostomy (30.89% vs 51.40%, P = 0.006), biliary plasty requirement (19.51% vs 40.16%, P = 0.001), shorter LOS (mean 14.32 vs 17.95 d, P < 0.001), and lower severe complication (CD ≥ III) (12.11% vs. 22.88%, P = 0.006) were observed in the LS group compared with the OP group. Major postoperative complications such as hemorrhage, biliary fistula, abdominal abscess, and hepatic insufficiency were similar between LS and OP (P > 0.05 for all). After PSM, the short-term outcomes of two surgical methods were similar, except for shorter LOS in LS compared with OP (mean 15.19 vs 18.48 d, P = 0.0007). A series subgroup analysis demonstrated that LS was safe and had advantages in shorting LOS.

conclusionAlthough the complex surgical procedures, LS generally seems to be safe and feasible for experienced surgeons.

trial registrationNCT05402618 (date of first registration: 02/06/2022).

Indexed as

Bile Duct NeoplasmsKlatskin TumorLaparoscopyHumansLength of StayPostoperative ComplicationsPropensity ScoreRetrospective StudiesTreatment OutcomeLaparoscopicOpen resectionPerihilar cholangiocarcinomaShort-term outcomes

Identifiers

PMID37138243
PMCPMC10157952
OpenAlexW4367856539

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.