ArticleBMC women's health2023
Association between serum uric acid and female infertility: a cross-sectional study of National Health and Nutrition Examination Survey (NHANES) 2013-2018.
Article in BMC women's health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Association between the serum uric acid-to-HDL-cholesterol ratio and female infertility: The mediating role of BMI.Medicine · 2026Article
- The relationship between high serum UA levels and decidualization and angiogenesis in endometrium.Scientific reports · 2025Article
- Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study.European journal of medical research · 2025Article
- Adherence to a healthy lifestyle in association with female infertility risk: the mediating role of uric acid.Frontiers in nutrition · 2025Article
- Association Between Weight-Adjusted Waist Index (WWI) and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional Analysis of NHANES Data.International journal of endocrinology · 2025Article
- Effect of Dietary Magnesium on the Association Between Serum Uric Acid and Female Infertility.International journal of women's health · 2025Article
- The Association Between Sleep Disorder and Female Infertility: A Mediation Analysis of Inflammatory and Oxidative Markers.Mediators of inflammation · 2025Article
- The Causal Effect of Urate Level on Female Infertility: A Mendelian Randomization Study.Metabolites · 2024Article
- Decoding connections in the European population: serum uric acid, sex hormone-binding globulin, total testosterone, estradiol, and female infertility - advanced bidirectional and mediative Mendelian randomization.Frontiers in endocrinology · 2024Article
- Association between oxidative balance score and female infertility from the national health and nutrition examination survey 2013-2018.Frontiers in endocrinology · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFemale infertility is a major problem for women of reproductive-age worldwide. Oxidative stress and inflammation are involved in processes related to female infertility. Serum uric acid levels, an indicator of oxidative stress and inflammation, have rarely been reported to be associated with female infertility. This study aimed to investigate the relationship between serum uric acid levels and female infertility.
methodsThis cross-sectional study included women aged 18-44 years from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2018. All data were extracted from NHANES questionnaires and laboratory measurements. Weighted univariable and multivariable logistic regression analyses were utilized to explore the relationship between serum uric acid and female infertility. Stratified analyses were performed based on body mass index (BMI, < 25 kg/m
resultsA total of 2,884 women were included, of which 352 (13.30%) had infertility. Women with high serum uric acid concentrations were related to higher odds of infertility (OR = 1.20, 95%CI: 1.03-1.39) after adjusting for confounders. Compared with serum uric acid concentrations ≤ 3.72 mg/dL, women with uric acid concentrations of 4.43-5.13 mg/dL (OR = 1.65, 95%CI: 1.02-2.67) and > 5.13 mg/dL (OR = 1.86, 95%CI: 1.10-3.13) were related to higher odds of infertility. Stratified analyses showed that high serum uric acid concentrations were associated with higher odds of infertility in women with a BMI < 25 kg/m
conclusionWomen with high serum uric acid concentrations were associated with higher odds of infertility, and this association may vary by BMI and age.
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