Evidence map›Paper›PMID 37138223›Full record

Trial reportBMC anesthesiology2023

Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial.

Wael Fathy, Mona Hussein, Rehab Magdy, Hanan H Soliman, Hatem Elmoutaz, Alaa A Meshref, Reem M Sabry, Marwa A Elgaly, Mohammed Fawaz, Dina Y Kassim

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wael FathyDepartment of Anesthesia, Surgical ICU and Pain management, Beni-Suef University, Beni-Suef, Egypt. drwaelfathy@med.bsu.edu.eg.
Mona HusseinDepartment of Neurology, Beni-Suef University, Beni-Suef, Egypt.
Rehab MagdyDepartment of Neurology, Cairo University, Cairo, Egypt.
Hanan H SolimanNeuro diagnostic research center, Beni-Suef University, Beni-Suef, Egypt.
Hatem ElmoutazDepartment of Anesthesia, Surgical ICU and Pain management, Beni-Suef University, Beni-Suef, Egypt.
Alaa A MeshrefNeuro diagnostic research center, Beni-Suef University, Beni-Suef, Egypt.
Reem M SabryNeuro diagnostic research center, Beni-Suef University, Beni-Suef, Egypt.
Marwa A ElgalyNeuro diagnostic research center, Beni-Suef University, Beni-Suef, Egypt.
Mohammed FawazDepartment of Otorhinolaryngology, Beni-Suef University, Beni-Suef, Egypt.
Dina Y KassimDepartment of Anesthesia, Surgical ICU and Pain management, Beni-Suef University, Beni-Suef, Egypt.
Beni-Suef University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative cognitive dysfunction is a noteworthy complication of deliberate hypotensive anesthesia. The aim of this work was to compare the effect of deliberate hypotensive anesthesia using nitroglycerine versus phentolamine on event-related potentials and cognitive function in patients undergoing septoplasty surgery.

methodsThis prospective randomized controlled trial was conducted on 80 patients indicated for septoplasty under general anesthesia; 40 patients received intra-operative Nitroglycerine and 40 patients received intra-operative Phentolamine. Cognitive assessment (using Paired Associate Learning test (PALT) and Benton Visual Retention test (BVRT)) and P300 recording were done for all included patients pre-operatively and one week postoperatively.

resultsThe scores of PALT and Benton BVRT significantly declined one week following surgery in both Nitroglycerine and Phentolamine groups. There was no statistically significant difference between Nitroglycerine and Phentolamine groups in the postoperative decline in either PALT or BVRT (P-value = 0.342, 0.662 respectively). The values of P300 latency showed a significant delay one week following surgery in both Nitroglycerine and Phentolamine groups (P-value ≤ 0.001, 0.001), but in Nitroglycerine group, the delay is significantly higher than in Phentolamine group (P-value = 0.003). The values of P300 amplitude significantly decreased one week following surgery in both Nitroglycerine and Phentolamine groups (P-value ≤ 0.001, 0.001), but there was no statistically significant difference between Nitroglycerine and Phentolamine groups (P-value = 0.099).

conclusionPhentolamine is preferred over nitroglycerin in deliberate hypotensive anesthesia because it has less harmful effect on cognitive function than nitroglycerin.

Indexed as

CognitionNitroglycerinAnesthesia, GeneralEvoked PotentialsHumansPhentolamineProspective StudiesNitroglycerinPhentolamineBVRTDeliberate hypotensive anesthesiaNitroglycerineP300PALTPhentolamine

Identifiers

PMID37138223
PMCPMC10155363
OpenAlexW4367844347

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.