Evidence map›Paper›PMID 37138184›Full record

ReviewMolecular psychiatry2023

Coordination of RNA modifications in the brain and beyond.

Anthony Yulin Chen, Michael C Owens, Kathy Fange Liu

Open access · greenAbstract readReview
In one paragraph

Review in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Expandingthe Phenotypic Spectrum ofMolecular syndromology · 2026
    Article
  4. NSUN7 is a catalytically inactive RNA mNature communications · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. N1-methylation of adenosine (mMolecular psychiatry · 2024
    Article
  10. Epitranscriptomic Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Anthony Yulin Chen *Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Michael C Owens *Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0001-9425-106X
Kathy Fange LiuDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA. liufg@pennmedicine.upenn.edu.ORCID 0000-0001-5943-3888
University of Pennsylvania · USSwarthmore College · US

Funding

Structural biology and molecular biophysics training programT32GM132039 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ben E. Black, Elizabeth Rhoades · 2019 to 2026
$3.3M
Coregulation of mRNA, tRNA, and rRNA species through RNA modificationsR35GM133721 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LIU, FANGE · 2019 to 2023
$2.5M
Catalytic roles of RNA methyltransferase DIMT1R01HL160726 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI COOPERMAN, BARRY S., LIU, FANGE · 2022 to 2025
$2.4M
NHLBI NIH HHS R01 HL160726NIGMS NIH HHS R35 GM133721NIGMS NIH HHS T32 GM132039
6 · The paper itself

Abstract

Gene expression regulation is a critical process throughout the body, especially in the nervous system. One mechanism by which biological systems regulate gene expression is via enzyme-mediated RNA modifications, also known as epitranscriptomic regulation. RNA modifications, which have been found on nearly all RNA species across all domains of life, are chemically diverse covalent modifications of RNA nucleotides and represent a robust and rapid mechanism for the regulation of gene expression. Although numerous studies have been conducted regarding the impact that single modifications in single RNA molecules have on gene expression, emerging evidence highlights potential crosstalk between and coordination of modifications across RNA species. These potential coordination axes of RNA modifications have emerged as a new direction in the field of epitranscriptomic research. In this review, we will highlight several examples of gene regulation via RNA modification in the nervous system, followed by a summary of the current state of the field of RNA modification coordination axes. In doing so, we aim to inspire the field to gain a deeper understanding of the roles of RNA modifications and coordination of these modifications in the nervous system.

Indexed as

Gene Expression RegulationRNABrainEpigenesis, GeneticRNA

Identifiers

PMID37138184
PMCPMC11758487
OpenAlexW4367844866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.