Evidence map›Paper›PMID 37138138›Full record

ArticleMolecular biology reports2023

Interleukin-16 genetic polymorphisms in Guangxi Chinese with hepatitis B virus-related liver cirrhosis.

Xiaolian Zhang, Wenjun Tang, Xue Qin, Shan Li, Dong Liang

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xiaolian Zhang *Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Wenjun TangDepartment of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
Xue Qin *Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Shan Li *Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. lis8858@126.com.
Dong LiangMedical Equipment Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Zengar463@163.com.
Guangxi Medical University · CNFirst Affiliated Hospital of GuangXi Medical University · CNGuilin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur previous study has reported that interleukin-16 (IL-16) genetic polymorphisms are significantly related to chronic hepatitis B (CHB) and hepatitis B virus-related (HBV-related) hepatocellular carcinoma (HCC). As CHB, liver cirrhosis (LC), and HCC are development processes, this study aimed to determine genetic correlation of IL-16 polymorphisms with HBV-related LC in a Chinese population.

methodsIL-16 gene rs11556218, rs4072111, and rs4778889 polymorphism in 129 patients with HBV-related LC and 168 healthy individuals were genotyped via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). PCR-RFLP results were verified by DNA sequencing.

resultsThe allelic and genotypic distributions of IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms in HBV-related LC patients showed no significant difference from those in healthy controls. Furthermore, no relationship was observed between the haplotype distribution and susceptibility to HBV-related LC.

conclusionsThis work provided the first evidence that the IL-16 genetic polymorphisms may not be associated with HBV-related LC risk.

Indexed as

Hepatitis B, ChronicInterleukin-16Liver CirrhosisCase-Control StudiesChinaEast Asian PeopleGenetic Predisposition to DiseaseGenotypeHepatitis B virusHumansPolymorphism, Single NucleotideIl16 protein, humanInterleukin-16Interleukin-16Liver cirrhosisPolymorphisms

Identifiers

PMID37138138
OpenAlexW4367849494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.