Evidence map›Paper›PMID 37138135›Full record

ReviewPharmaceutical research2023

Drug complexes: Perspective from Academic Research and Pharmaceutical Market.

Siva Ram Munnangi, Ahmed Adel Ali Youssef, Nagarjuna Narala, Preethi Lakkala, Sagar Narala, Sateesh Kumar Vemula, Michael Repka

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmaceutical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  12. Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siva Ram MunnangiDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, MS, 38677, USA.
Ahmed Adel Ali YoussefDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, MS, 38677, USA.
Nagarjuna NaralaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, MS, 38677, USA.
Preethi LakkalaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, MS, 38677, USA.
Sagar NaralaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, MS, 38677, USA.
Sateesh Kumar VemulaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, MS, 38677, USA.
Michael RepkaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, MS, 38677, USA. marepka@olemiss.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main problem encountered during the formulation development of new actives and for generic development. A complexation approach has been widely investigated to address this issue, which subsequently improves the bioavailability of these drugs. This review discusses the various types of complexes such as metal complex (drug-metal ion), organic molecules (drug-caffeine or drug-hydrophilic polymer), inclusion complex (drug-cyclodextrin), and pharmacosomes (drug-phospholipids) that improves the aqueous solubility, dissolution, and permeability of the drug along with the numerous case studies reported in the literature. Besides improving solubility, drug-complexation provides versatile functions like improving stability, reducing the toxicity of drugs, increasing or decreasing the dissolution rate, and enhancing bioavailability and biodistribution. Apart, various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex are discussed.

Indexed as

CyclodextrinsBiological AvailabilityPharmaceutical PreparationsSolubilityTissue DistributionWaterCyclodextrinsPharmaceutical PreparationsWatercomplexationcyclodextrinsion-resin complexationorganic molecular complexespharmacosomesphase solubility

Identifiers

PMID37138135
PMCPMC10156076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.