ArticleNature2023
Glioblastoma remodelling of human neural circuits decreases survival.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06617208 (Prognostic IntraOperative Biomarkers ideNtification in Tumor rElatEd suRgery), which is not on this map. Cited by 257 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
257citing papers in PubMed, 1 pooled it
51.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic IntraOperative Biomarkers ideNtification in Tumor rElatEd suRgery (PIONEER Study)
Who cites it
257 citing papers in PubMed, 1 synthesis or guideline pooled it, 334 citations in OpenAlex.
- Surgical identification of brain tumour margins through impedance monitoring and electrocorticography and the potential for their combined use: A systematic review.Neurosurgical review · 2024Pooled it
- Factors Associated With Perceived Cognitive Dysfunction in Patients With Primary Brain Tumors: The Utility of the Neuro-QoL Cognition Function Scale.Cancer medicine · 2026Observational
- The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma.Immunology and cell biology · 2026Review
- Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced CaNature cancer · 2026Article
- nTMS-determined cortical excitability is associated with overall survival in patients with motor-eloquent glioblastoma.Journal of neuro-oncology · 2026Article
- Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma.Nature medicine · 2026Article
- Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth.Cell · 2026Article
- Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Glioblastoma recurrence: An NGS-centered seed-soil framework.Neoplasia (New York, N.Y.) · 2026Article
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- Identification of abnormal neural language networks by reading "brainprints" in patients with brain tumors.Neuroimage. Reports · 2026Article
- T-cell immunoglobulin and mucin-domain containing-3 orchestrates myeloid dysfunction across brain aging and disease.Neural regeneration research · 2026Article
- Gabapentin and cognitive impairment after traumatic brain injury: A multinational cohort of 49,925 patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Neuro-immune crosstalk in lung cancer brain metastasis: mechanisms, therapeutic targets, and translational opportunities.Medical oncology (Northwood, London, England) · 2026Review
- Targeting tumour-neuron synapses with intracavitary RNA delivery prevents glioblastoma recurrence.Nature biomedical engineering · 2026Article
- A Neuro-Immune Score Defines a Stromal-Neural and Immune-Segregated Microenvironment Associated with Poor Prognosis in Colorectal Cancer.International journal of molecular sciences · 2026Article
- Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT.Nature communications · 2026Article
- Mechanisms, Microenvironments, and Models: Understanding Therapeutic Resistance in Glioblastoma.International journal of radiation oncology, biology, physics · 2026Review
- Organoids as brain tumour models: bridging the translational gap.Disease models & mechanisms · 2026Review
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
197 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
29 authors at 4 institutions in 1 country.
Saritha KrishnaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Abrar ChoudhuryDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8312-2457
Michael B KeoughDepartment of Neurology, Stanford University, Stanford, CA, USA.
Kyounghee SeoDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Lijun NiDepartment of Neurology, Stanford University, Stanford, CA, USA.
Sofia KakaizadaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Anthony LeeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Alexander AabediDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7935-5458
Galina PopovaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8249-219X
Benjamin LipkinDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7465-5315
Caroline CaoDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Cesar Nava GonzalesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Rasika SudharshanDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Andrew EgladyousDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Nyle AlmeidaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Yalan ZhangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Annette M MolinaroDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9854-7404
Humsa S VenkateshDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1194-3015
Andy G S DanielDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Kiarash ShamardaniDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2548-705X
Jeanette HyerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2480-4700
Anne FindlayDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Joanna J PhillipsDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3789-8120
Srikantan NagarajanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
David R RaleighDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9299-8864
David BrangDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Michelle MonjeDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3547-237X
Shawn L Hervey-JumperDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. Shawn.Hervey-Jumper@ucsf.edu.ORCID 0000-0003-4699-260X
University of California, San Francisco · USStanford University · USUniversity of Michigan · USHoward Hughes Medical Institute · US
Funding
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4MTargeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WENDY Beth LONDON · 2013 to 2026
$33.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MTargeting the neuronal microenvironment in glioblastomaU19CA264504 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Tracy T Batchelor · 2021 to 2026
$6.4MLeveraging doxorubicin immune-modulation, blood-brain barrier opening, and personalized medicine for effective immunotherapy in glioblastoma. A mechanistic approach and pharmacokinetic trial.U19CA264338 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adam M Sonabend · 2021 to 2026
$5.8MGlioma Circuitry: Bridging Systems Neuroscience and CancerDP1NS111132 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2018 to 2022
$5.7MDynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6MDeveloping Safe and Effective GD2-CAR T Cell Therapy for Diffuse Midline GliomasR01CA263500 · NCI · STANFORD UNIVERSITY · PI MACKALL, CRYSTAL, MONJE-DEISSEROTH, MICHELLE · 2021 to 2025
$3.3MNeuronal Regulation of Low-Grade GliomagenesisR01CA258384 · NCI · STANFORD UNIVERSITY · PI David H Gutmann, Michelle Monje-Deisseroth · 2022 to 2026
$3.1MMechanisms of Hedgehog signaling in glioblastomaR01CA251221 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RALEIGH, DAVID R · 2021 to 2025
$2.6MNeuronal activity-regulated mechanisms of glioma growthR01NS092597 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2016 to 2021
$2.1MIntratumoral functional connectivity with implications on synaptogenesis and aphasia recovery in adult astrocytic WHO II-III gliomaK08NS110919 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERVEY-JUMPER, SHAWN L. · 2019 to 2023
$1.0MNCI NIH HHS F30 CA246808NCI NIH HHS K08 CA212279NCI NIH HHS K99 CA252001NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA165962NCI NIH HHS R01 CA251221NCI NIH HHS R01 CA258384NCI NIH HHS R01 CA263500NCI NIH HHS R21 CA264339NCI NIH HHS U19 CA264338NCI NIH HHS U19 CA264504NIDCD NIH HHS R00 DC013828NIGMS NIH HHS T32 GM007618NINDS NIH HHS DP1 NS111132NINDS NIH HHS K08 NS110919NINDS NIH HHS R01 NS092597NINDS NIH HHS R01 NS100440
Abstract
Gliomas synaptically integrate into neural circuits
Indexed as
Brain NeoplasmsGlioblastomaNeural PathwaysBiopsyBrainCell ProliferationCognitionDisease ProgressionGabapentinHumansSurvival RateThrombospondin 1WakefulnessGabapentinThrombospondin 1thrombospondin-1, human
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Read underepoch 390
Registered trials
NCT06617208ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.