Evidence map›Paper›PMID 37138042›Full record

ReviewSeminars in immunopathology2023

Immune compartments at the brain's borders in health and neurovascular diseases.

Jennifer E Goertz, Lidia Garcia-Bonilla, Costantino Iadecola, Josef Anrather

Abstract readReview
In one paragraph

Review in Seminars in immunopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Isolating Immune Cells from Mouse Brain and Skull.Journal of visualized experiments : JoVE · 2024
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer E GoertzFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61St Street; RR-405, New York, NY, 10065, USA.
Lidia Garcia-BonillaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61St Street; RR-405, New York, NY, 10065, USA.
Costantino IadecolaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61St Street; RR-405, New York, NY, 10065, USA.
Josef AnratherFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61St Street; RR-405, New York, NY, 10065, USA. joa2006@med.cornell.edu.ORCID 0000-0002-0468-9162

Funding

NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER01NS034179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1995 to 2021
$5.5M
Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular RiskR01NS095441 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2025
$4.7M
ApoE4, Neurovascular Injury and Cognitive ImpairmentR01NS126467 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Costantino Iadecola · 2022 to 2026
$4.1M
Protective monocytes in cerebral ischemic toleranceR01NS081179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANRATHER, JOSEF · 2012 to 2022
$3.7M
Hypertension and neurovascular dysfunctionR37NS089323 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2015 to 2021
$3.1M
Immunomodulation by Commensal Microbiota: Role in Ischemic Brain InjuryR01NS094507 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANRATHER, JOSEF · 2016 to 2020
$1.9M
The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic StrokeR01NS132493 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Josef Anrather · 2023 to 2026
$1.8M
EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTORR01HL035753 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI GARDNER, DAVID G · 1985 to 2002
$996k
NHLBI NIH HHS R01 HL035753NINDS NIH HHS R01 NS034179NINDS NIH HHS R01 NS081179NINDS NIH HHS R01 NS094507NINDS NIH HHS R01 NS095441NINDS NIH HHS R01 NS126467NINDS NIH HHS R01 NS132493NINDS NIH HHS R37 NS089323
6 · The paper itself

Abstract

Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been described for cardiovascular diseases such as hypertension and stroke. In this review, we will examine the cellular composition of these cranial border immune niches, the potential pathways through which they might interact, and the evidence linking them to cardiovascular disease.

Indexed as

BrainMeningesHumansBorder-associated immune cellsBrainCalvariaChoroid plexusCirumventricular organsHypertensionMeningesNeuroinflammationSkull bone marrowStroke

Identifiers

PMID37138042
PMCPMC10279585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.