Evidence map›Paper›PMID 37137974›Full record

ArticleCommunications biology2023

Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species.

Odion O Ikhimiukor, Stephanie S R Souza, Michael M Marcovici, Griffin J Nye, Robert Gibson, Cheryl P Andam

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Odion O IkhimiukorDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA. oikhimiukor@albany.edu.ORCID 0000-0002-3738-4584
Stephanie S R SouzaDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Michael M MarcoviciDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Griffin J NyeDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Robert GibsonDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Cheryl P AndamDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA. candam@albany.edu.ORCID 0000-0003-4428-0924
Albany State University · USUniversity of New Hampshire · US

Funding

Population and evolutionary dynamics of recombining genes and alleles in bacteriaR35GM142924 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Cheryl Marie P Andam · 2021 to 2026
$1.9M
NIGMS NIH HHS R35 GM142924
6 · The paper itself

Abstract

Coagulase-negative Staphylococcus (CoNS) are opportunistic pathogens implicated in many human and animal infections. The evolutionary history of CoNS remains obscure because of the historical lack of recognition for their clinical importance and poor taxonomic sampling. Here, we sequenced the genomes of 191 CoNS isolates representing 15 species sampled from diseased animals diagnosed in a veterinary diagnostic laboratory. We found that CoNS are important reservoirs of diverse phages, plasmids and mobilizable genes encoding antimicrobial resistance, heavy metal resistance, and virulence. Frequent exchange of DNA between certain donor-recipient partners suggests that specific lineages act as hubs of gene sharing. We also detected frequent recombination between CoNS regardless of their animal host species, indicating that ecological barriers to horizontal gene transfer can be surmounted in co-circulating lineages. Our findings reveal frequent but structured patterns of transfer that exist within and between CoNS species, which are driven by their overlapping ecology and geographical proximity.

Indexed as

BacteriophagesCoagulaseAnimalsHumansPlasmidsStaphylococcusCoagulase

Identifiers

PMID37137974
PMCPMC10156822
OpenAlexW4367839709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.